Date published: 2026-4-24

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(±) Menthol-d4 (CAS 89-78-1 (unlabeled))

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Alternate Names:
DL-Menthol-d4
Application:
(±) Menthol-d4 is a TRPM8 receptor agonist
CAS Number:
89-78-1 (unlabeled)
Molecular Weight:
160.20
Molecular Formula:
C10H16D4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(±) Menthol-d4 is a TRPM8 receptor agonist. (±) Menthol-d4 is the deuterium-labeled form of menthol, a natural analgesic compound. Menthol is known to induce a cooling sensation by inhibiting calcium ion (Ca++) currents on neuronal membranes, which stimulates the "cold" receptors.


(±) Menthol-d4 (CAS 89-78-1 (unlabeled)) References

  1. Systemic exposure to menthol following administration of peppermint oil to paediatric patients.  |  Kearns, GL., et al. 2015. BMJ Open. 5: e008375. PMID: 26270949
  2. Determination of Menthol in Plasma and Urine by Gas Chromatography/Mass Spectrometry (GC/MS).  |  Peat, J., et al. 2016. Methods Mol Biol. 1383: 205-11. PMID: 26660189
  3. Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.  |  Oviedo, A., et al. 2016. Regul Toxicol Pharmacol. 81 Suppl 2: S93-S122. PMID: 27818348

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±) Menthol-d4, 2.5 mg

sc-218692
2.5 mg
$315.00

How much liquid does the vial hold, if I add 1 mL what will my concentration of menthol-d4 be?

Asked by: cinco
Thank you for your question. We do not provide this as a liquid. It is provided as 2.5 mg in oil. We do not know the volume. Solubility of the product is 3mg/mL of chloroform.
Answered by: Technical Support
Date published: 2017-10-17

Any recommendations or protocols for making up a standard solution for GC analysis?

Asked by: cinco
Thank you for your question. We have not tested this product by GC as it is not part of our routine analysis. I would recommend preparing a stock solution in chloroform. We have tested the solubility in 3mg/mL of chloroform, however you may try a more dilute solution if you wish.
Answered by: Technical Support
Date published: 2017-10-05

What are some recommended solvents?

Asked by: chemicalsmg
Thank you for your question. (+/-) Menthol-d4: sc-218692 is slightly soluble in chloroform or methanol.
Answered by: Chemical Support 3
Date published: 2017-04-07

What is the expected appearance?

Asked by: chemicalsmg
Thank you for your question. (+/-) Menthol-d4: sc-218692 is expected to be a clear, colorless oil.
Answered by: Chemical Support 3
Date published: 2017-04-07
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Date published: 2024-12-20
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