(±)-Lisofylline (CAS 6493-06-7)
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(±)-Lisofylline is a synthetic methylxanthine metabolite of Pentoxifylline (sc-203184) and an inhibitor of phosphatidic acid generation. Suppression of lipopolysaccharide (LPS)-induced phosphatidic acid generation by (±)-Lisofylline was demonstrated to protect BALB/c mice against septic shock and LPS-associated endotoxin lethality. (±)-Lisofylline exhibits antiinflammatory effects, demonstrated to inhibit production of TNF-alpha stimulated by LPS, block the release of pro-inflammatory cytokines in response to oxidative injury, and inhibit interleukin-12 (IL-12) signaling activity. Suppression of IL-12 by (±)-Lisofylline is shown to interrupt activation of STAT4 (signal transducer and activator of transcription factor-4), blocking autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice.
(±)-Lisofylline (CAS 6493-06-7) References
- Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes. | Yang, Z., et al. 2003. Ann N Y Acad Sci. 1005: 409-11. PMID: 14679102
- Lisofylline: a potential lead for the treatment of diabetes. | Yang, Z., et al. 2005. Biochem Pharmacol. 69: 1-5. PMID: 15588708
- Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide. | Wyska, E. 2010. Pharmacology. 85: 264-71. PMID: 20389149
- Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. | Rice, GC., et al. 1994. Proc Natl Acad Sci U S A. 91: 3857-61. PMID: 8171002
- The effects of post-treatment with lisofylline, a phosphatidic acid generation inhibitor, on sepsis-induced acute lung injury in pigs. | Hasegawa, N., et al. 1997. Am J Respir Crit Care Med. 155: 928-36. PMID: 9117028
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Lisofylline, 10 mg | sc-201055 | 10 mg | $189.00 | |||
(±)-Lisofylline, 25 mg | sc-201055B | 25 mg | $260.00 | |||
(±)-Lisofylline, 50 mg | sc-201055A | 50 mg | $423.00 | |||
(±)-Lisofylline, 100 mg | sc-201055C | 100 mg | $780.00 | |||
(±)-Lisofylline, 250 mg | sc-201055D | 250 mg | $1637.00 |