Molecular structure of (±)-Hesperetin, CAS Number: 520-33-2
(±)-Hesperetin (CAS 520-33-2)
See product citations (4)
Application:
(±)-Hesperetin is an antioxidant flavonoid
CAS Number:
520-33-2
Purity:
>95%
Molecular Weight:
302.3
Molecular Formula:
C16H14O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(±)-Hesperetin is an antioxidant flavonoid. The precise mechanism by which (±)-Hesperetin operates remains under ongoing investigation. Current understanding suggests that (±)-Hesperetin exerts its effects by modulating the expression of specific genes and suppressing NF-kappaB activation. Additionally, (±)-Hesperetin is believed to possess the ability to scavenge free radicals and inhibit the activity of enzymes responsible for producing inflammatory molecules.
(±)-Hesperetin (CAS 520-33-2) References
- Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. | Kim, HK., et al. 2003. Clin Chim Acta. 327: 129-37. PMID: 12482628
- Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin. | Kim, JY., et al. 2006. Aging Cell. 5: 401-11. PMID: 16939486
- Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin. | Cho, J. 2006. Arch Pharm Res. 29: 699-706. PMID: 16964766
- Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21. | Choi, EJ. 2007. Nutr Cancer. 59: 115-9. PMID: 17927510
- Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. | Parhiz, H., et al. 2015. Phytother Res. 29: 323-31. PMID: 25394264
- Flavanones: Citrus phytochemical with health-promoting properties. | Barreca, D., et al. 2017. Biofactors. 43: 495-506. PMID: 28497905
- Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model. | Ikram, M., et al. 2019. Mol Neurobiol. 56: 6293-6309. PMID: 30756299
- Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling. | Muhammad, T., et al. 2019. Nutrients. 11: PMID: 30884890
- Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. | Chen, X., et al. 2019. Chem Biol Interact. 308: 269-278. PMID: 31153982
- Hesperetin ameliorates DSS-induced colitis by maintaining the epithelial barrier via blocking RIPK3/MLKL necroptosis signaling. | Zhang, J., et al. 2020. Eur J Pharmacol. 873: 172992. PMID: 32035144
- Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis. | Liu, P., et al. 2021. Biomed Pharmacother. 139: 111552. PMID: 33839495
- Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. | Li, J., et al. 2021. Food Funct. 12: 3898-3918. PMID: 33977953
- Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway. | Zhu, X., et al. 2021. Metab Brain Dis. 36: 1969-1983. PMID: 34273043
- Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health. | Ortiz, AC., et al. 2022. Biomolecules. 12: PMID: 35625554
- Structure-antioxidant activity relationships of flavonoids and phenolic acids. | Rice-Evans, CA., et al. 1996. Free Radic Biol Med. 20: 933-56. PMID: 8743980
Inhibitor of:
CYP4A12A, Cyp4f15, GDF-5, UGT2B37, and UGT2B5.Activator of:
BBS9, COL10A1, HRT1_Hrt1, Nrf2, and TRNP-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Hesperetin, 1 g | sc-202647 | 1 g | $47.00 |