Molecular structure of (±)-Clopidogrel hydrochloride, CAS Number: 90055-48-4
(±)-Clopidogrel hydrochloride (CAS 90055-48-4)
Alternate Names:
Plavix; Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrochloride
Application:
(±)-Clopidogrel hydrochloride is a high affinity, selective P2Y12 receptor antagonist
CAS Number:
90055-48-4
Molecular Weight:
358.28
Molecular Formula:
C16H16NO2SCl•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-Clopidogrel hydrochloride is a thienopyridine adenosine diphosphate (ADP)-receptor antagonist. In addition, this ligand functions as a selective irreversible P2Y12 receptor antagonist. It is known that P2Y12 are ADP receptors located on platelet membranes and are responsible for platelet aggregation and cross-linking by fibrin. This mechanism involves blocking the activation of glycoprotein IIb/IIIa. It is known that (±)-Clopidogrel hydrochloride interacts with the ADP receptor by forming disulfide bonds. Furthermore, (±)-Clopidogrel hydrochloride is activated by cytochrome P450 enzymes from the liver, specifically CYP2C19.
(±)-Clopidogrel hydrochloride (CAS 90055-48-4) References
- P2y(12), a new platelet ADP receptor, target of clopidogrel. | Savi, P., et al. 2001. Biochem Biophys Res Commun. 283: 379-83. PMID: 11327712
- Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. | Savi, P. and Herbert, JM. 2005. Semin Thromb Hemost. 31: 174-83. PMID: 15852221
- Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. | von Kügelgen, I. 2006. Pharmacol Ther. 110: 415-32. PMID: 16257449
- Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. | Swales, KE., et al. 2012. Cardiovasc Res. 93: 674-81. PMID: 22166712
Inhibitor of:
CYP2B1, and P2Y12.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Clopidogrel hydrochloride, 10 mg | sc-203553 | 10 mg | $138.00 | |||
(±)-Clopidogrel hydrochloride, 50 mg | sc-203553A | 50 mg | $587.00 |