Molecular structure of (±)-Blebbistatin, CAS Number: 674289-55-5
(±)-Blebbistatin (CAS 674289-55-5)
See product citations (7)
Alternate Names:
Blebbistatin is known as a racemic mixture of (–)-blebbistatin and (+)-blebbistatin.
Application:
(±)-Blebbistatin is a selective inhibitor of nonmuscle myosin II ATPase and several striated muscle myosins.
CAS Number:
674289-55-5
Purity:
≥96%
Molecular Weight:
292.34
Molecular Formula:
C18H16N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-Blebbistatin is a chemical compound that has been the subject of extensive research in the field of biochemistry and cell biology. It is a potent inhibitor of myosin II, a motor protein involved in various cellular processes, such as cell division, muscle contraction, and cytokinesis. (±)-Blebbistatin can be used as a research tool for studying the functions of myosin II in cells and model organisms. By inhibiting the activity of myosin II, (±)-Blebbistatin can be used to investigate the effects of myosin II inhibition on various cellular processes, such as cell motility, adhesion, and morphology. Researchers have investigated the use of (±)-Blebbistatin as a substrate for the production of other chemical compounds or as a starting material for the synthesis of new compounds. Another area of research on (±)-Blebbistatin is its use as a model compound for studying chemical reactions and mechanisms. It can also be used to investigate fundamental chemical processes, such as enzyme inhibition and protein-ligand interactions.
(±)-Blebbistatin (CAS 674289-55-5) References
- Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. | Straight, AF., et al. 2003. Science. 299: 1743-7. PMID: 12637748
- Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor. | Duxbury, MS., et al. 2004. Biochem Biophys Res Commun. 313: 992-7. PMID: 14706640
- Specificity of blebbistatin, an inhibitor of myosin II. | Limouze, J., et al. 2004. J Muscle Res Cell Motil. 25: 337-41. PMID: 15548862
- Blebbistatin and blebbistatin-inactivated myosin II inhibit myosin II-independent processes in Dictyostelium. | Shu, S., et al. 2005. Proc Natl Acad Sci U S A. 102: 1472-7. PMID: 15671182
- Blebbistatin, a myosin II inhibitor, suppresses contraction and disrupts contractile filaments organization of skinned taenia cecum from guinea pig. | Watanabe, M., et al. 2010. Am J Physiol Cell Physiol. 298: C1118-26. PMID: 20164381
- Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heart. | Jou, CJ., et al. 2010. Cell Physiol Biochem. 25: 419-24. PMID: 20332622
- A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. | Várkuti, BH., et al. 2016. Sci Rep. 6: 26141. PMID: 27241904
- Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2. | Zhang, HM., et al. 2017. Biochemistry. 56: 4235-4243. PMID: 28714309
- Medicinal Chemistry and Use of Myosin II Inhibitor (S)-Blebbistatin and Its Derivatives. | Roman, BI., et al. 2018. J Med Chem. 61: 9410-9428. PMID: 29878759
- Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential. | Rauscher, AÁ., et al. 2018. Trends Biochem Sci. 43: 700-713. PMID: 30057142
- Blebbistatin-Loaded Poly(d,l-lactide-co-glycolide) Particles For Treating Arthrofibrosis. | Atluri, K., et al. 2016. ACS Biomater Sci Eng. 2: 1097-1107. PMID: 33445238
- The effective use of blebbistatin to study the action potential of cardiac pacemaker cells of zebrafish (Danio rerio) during incremental warming. | Marchant James, L., et al. 2022. Curr Res Physiol. 5: 48-54. PMID: 35128467
- The myosin II inhibitor, blebbistatin, ameliorates pulmonary endothelial barrier dysfunction in acute lung injury induced by LPS via NMMHC IIA/Wnt5a/β-catenin pathway. | Zhang, J., et al. 2022. Toxicol Appl Pharmacol. 450: 116132. PMID: 35716767
Inhibitor of:
α-actinin-3, α-centractin, α-parvin, β1-Syntrophin, ε-sarcoglycan, 4.1B, 4930488E11Rik, A330021E22Rik, ACTL7B, Adducin β, ANK-1, Ankyrin B, Ankyrin-1, ARHGAP12, Astrotactin 2, ATPase, BAIAP2L2, BC028528, BC055111, beta-Actin, C18orf19, C20orf194, C20orf195, C20orf3, C22orf42, Caldesmon, Calpactin, Calponin 2, Calponin 3, CAP1, Ccdc163, CCDC53, Cdhr4, CHMP1B, CLDND2, CLP36, Cntnap5c, Coronin 1C, Coronin 2A, Coronin 6, CSPP1, Cylicin-2, Cytokeratin 15, DDEFL1, DENND5B, Desmuslin, DPY19L1, DSCAML1, E030010N08Rik, Ear14, Ear3, EG432995, EG434881, EG546400, EHBP1, EPB41L5, ephrin-A (EFNA), Espin, EXDL3, Extensin, FAM130A2, FAM21A, FAM21B, FBP21, FHOD1, Filamin 2, Flamingo, Flightless I, FNBP1L, FNDC3A, Formin Like (FMNL1, FMNL2), GIPC3, girdin, Gm14137, Gm732, GMF-γ, GMIP, HAPLN3, HEI10, HEPACAM2, HMP-2, HPV16 E4, IGSF4D, IQGAP2, JMY, KIAA0754, KIAA1199, KIAA1539, Lad, Laminin α-3, Laminin β-4, Laminin-5, LARP4, Liprin α2, LLGL1, LMO7, LOC221710, LOC653720, LPP, LRCH3, LUZP1, MIZIP, MLC, MOSPD2, MRLC2, MRTF-A, MSY3, MUSTN1, MYBPC1, MYBPH, MYH1, MYH11, MYH13, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH9, MYL1, Myl12a, MYL3, MYL6B, MYL9, Mylc2b, MyoD, myopalladin, Myosin Ib, Myosin Ic, Myosin Id, Myosin Ie, Myosin If, Myosin Ig, Myosin IIIa, Myosin IIIb, Myosin Va, Myosin Vb, Myosin Vc, Myosin VIIB, Myosin X, Myosin-neonatal, Myosin-XVA, Myotilin, MYPT1, MYPT3, N-RAP, N-WASP, NCKAP5L, Nebulette, NET1, netrin G1, Neuron navigator 2, NHSL1, NYAP2, Obscurin, Olfactomedin (OLFM), ORF19, OTTMUSG00000005523, PACSIN3, Pals1, PARD3B, PARD6G, PARV (parvin), Parvin beta, PCDH1_Pcdh1, PCDH2, PCDHA9, PCDHB, PCDHB11, Pcdhb17, PCDHGB2, periaxin, PHACTR2, Phakinin, PHLDB1, POP1, Profilin, Profilin-3, ProSAPiP1, PRR24, PRRG1, PRRG2, PSD, Psg16, PSG20, Punctin, R-PE, Rab11-FIP4, Rho 8, RSPH10B, Sall1, SEMA6B, Septin 12, Septin 3, Septin 4, Septin 9, SERINC5, SH3TC1, SHD1, SHROOM1, SIPA1L, Skn-1i, Slit1, SLITRK3, SMAP1, Smooth Muscle Actin, Smooth muscle cells, smoothelin, SNAPC 50, spectrin α I, Spi9, Spir-2, SRF, STAC, stefin A3, SUN1, SUN3, Synaptotagmin X, Tβ-15a, Talin-1, Tektin 3, Testin-2, TFG, THSD4, Titin, Tmsb15b1, TPBG, transgelin-3, TRIP6, Tropomyosin, Tropomyosin 4, Troponin I-FS, Troponin T-SS, TTC23, UNC45B, Vmn1r100, VWA3B, VWA5B1, VWA5B2, VWC2L, WDR92, Whirlin, Xinβ, zygin 1, and Zyxin.Activator of:
α-actinin-4, 2310002L09Rik, 2310044H10Rik, ABLIM3, AIP5, ARHGAP19, ARHGAP29, Arp3β, Arp7, BC055107, BC057079, C1QDC2, CCDC74A, CEP63, Cofilin 1, Cordon-bleu, Coronin 1B, Coronin 7, COTL1, CR16, CYFIP1, CYFIP2, Desmin, Dullard, EG432995, EPHEXIN, EPLIN, Eps8L3, FHOD3, FNDC1, GMF-β, GRAF, GRAP1, Hairy, HRF, IGSF3, INF2, Kindlin-3, LIMK-1, Lingo-1, LLGL2, MANSC4, MOB1B, Moesin, MRCKβ, MYLK, myomesin-1, Myosin Ia, Myosin VI, Myosin-13, Myosin-XVA, NECAP 2, NEURL1B, Nup210L, OBCAM, Pactolus, pan-Cytokeratin, PDZ-RhoGEF, Pinch-1, prefoldin 5, PRPF4, Rho H, SCAI, SEMA3D, SEMA4G, Shrm, spectrin β III, Stereocilin, SUN1, TAF6L, TAZ, tropomodulin 1, tropomodulin 2, tropomodulin 3, tropomodulin 4, Troponin T-C, Twinfilin-1, WDR1, WDR18, and ZBTB42.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Blebbistatin, 5 mg | sc-203532B | 5 mg | $183.00 | |||
(±)-Blebbistatin, 10 mg | sc-203532 | 10 mg | $313.00 | |||
(±)-Blebbistatin, 25 mg | sc-203532A | 25 mg | $464.00 | |||
(±)-Blebbistatin, 50 mg | sc-203532C | 50 mg | $942.00 | |||
(±)-Blebbistatin, 100 mg | sc-203532D | 100 mg | $1723.00 |