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(±)-Anatoxin A Fumarate (CAS 64285-06-9)

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Application:
(±)-Anatoxin A Fumarate is a cyanotoxin agonist of AChR
CAS Number:
64285-06-9
Purity:
≥96%
Molecular Weight:
281.31
Molecular Formula:
C10H15NO•C4H4O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(±)-Anatoxin A Fumarate is a synthetic analog of anatoxin-a, a neurotoxin originally found in certain species of cyanobacteria. As a research chemical, it is primarily used to study the cholinergic nervous system due to its agonistic activity on nicotinic acetylcholine receptors. This activity enables researchers to investigate the effects of overstimulation of these receptors, which is valuable for understanding the neurophysiological basis of conditions associated with cholinergic dysfunction. The compound′s action mimics the effects of acetylcholine, allowing for the study of synaptic transmission and the role of neurotransmitters in muscle contraction. Its fumarate salt form is favored in research applications for its stability and solubility properties.


(±)-Anatoxin A Fumarate (CAS 64285-06-9) References

  1. Cardio-respiratory changes and mortality in the conscious rat induced by (+)- and (+/-)-anatoxin-a.  |  Adeyemo, OM. and Sirén, AL. 1992. Toxicon. 30: 899-905. PMID: 1523681
  2. Activation and blockade of the acetylcholine receptor-ion channel by the agonists (+)-anatoxin-a, the N-methyl derivative and the enantiomer.  |  Kofuji, P., et al. 1990. J Pharmacol Exp Ther. 252: 517-25. PMID: 1690292
  3. Toxicology and detection methods of the alkaloid neurotoxin produced by cyanobacteria, anatoxin-a.  |  Osswald, J., et al. 2007. Environ Int. 33: 1070-89. PMID: 17673293
  4. Molecular mechanisms of the potent and stereospecific nicotinic receptor agonist (+)-anatoxin-a.  |  Swanson, KL., et al. 1986. Mol Pharmacol. 29: 250-7. PMID: 2419745
  5. Protection by a transdermal patch containing eserine and pralidoxime chloride for prophylaxis against (±)-Anatoxin A poisoning in rats.  |  Banerjee, S., et al. 2014. Eur J Pharm Sci. 56: 28-36. PMID: 24530375
  6. Synthetic and conformational studies on anatoxin-a: a potent acetylcholine agonist.  |  Koskinen, AM. and Rapoport, H. 1985. J Med Chem. 28: 1301-9. PMID: 4032432
  7. Anatoxin-a interactions with cholinergic synaptic molecules.  |  Aronstam, RS. and Witkop, B. 1981. Proc Natl Acad Sci U S A. 78: 4639-43. PMID: 6270690
  8. Anatoxin-a: a novel, potent agonist at the nicotinic receptor.  |  Spivak, CE., et al. 1980. Mol Pharmacol. 18: 384-94. PMID: 6970328
  9. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors.  |  Thomas, P., et al. 1993. J Neurochem. 60: 2308-11. PMID: 8492133

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±)-Anatoxin A Fumarate, 1 mg

sc-200185
1 mg
$450.00