Date published: 2026-5-24

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(±)9(10)-EpOME-d4

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Alternate Names:
(±)9(10)epoxy-12Z-octadecenoic 9,10,12,13-d4 acid; (±)9,10-EODE-d4; Leukotoxin-d4
Molecular Weight:
300.5
Molecular Formula:
C18H28D4O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(±)9(10)-EpOME-d4 is a deuterated version of 9(10)-epoxyoctadecenoic acid (9(10)-EpOME), which is an epoxide derivative of linoleic acid. This compound is part of a larger group of fatty acid epoxides that arise from the action of cytochrome P450 enzymes on unsaturated fatty acids. The introduction of four deuterium atoms in place of hydrogen in (±)9(10)-EpOME-d4 enhances its chemical stability and improves detection sensitivity in analytical techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, making it a valuable tool in biochemical research. These properties are particularly useful for studying the metabolic pathways and biological activities of its parent compound, 9(10)-EpOME, under various physiological conditions. Research involving (±)9(10)-EpOME-d4 focuses on its role in cellular mechanisms, such as signaling pathways that regulate inflammation and cellular proliferation. By tracing the interactions and transformations of (±)9(10)-EpOME-d4 within cellular systems, scientists can gain insights into the dynamics of epoxy fatty acids and their potential impact on cellular functions. This research offers a deeper understanding of lipid metabolism and the roles these lipid mediators play in maintaining cellular homeostasis and responding to environmental changes.


(±)9(10)-EpOME-d4 References

  1. Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.  |  Sisignano, M., et al. 2016. Proc Natl Acad Sci U S A. 113: 12544-12549. PMID: 27791151
  2. Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection.  |  Spillman, NJ., et al. 2016. mBio. 7: PMID: 27795395
  3. Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity.  |  Hu, J., et al. 2019. J Clin Invest. 129: 5204-5218. PMID: 31479425
  4. Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain.  |  Rimola, V., et al. 2020. J Neurosci. 40: 9519-9532. PMID: 33158961
  5. Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways.  |  Parks, SC., et al. 2021. PLoS Pathog. 17: e1010027. PMID: 34714893

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±)9(10)-EpOME-d4, 25 µg

sc-221170
25 µg
$100.00

(±)9(10)-EpOME-d4, 50 µg

sc-221170A
50 µg
$190.00