Molecular structure of (±)9(10)-EpOME, CAS Number: 6814-52-4
(±)9(10)-EpOME (CAS 6814-52-4)
Alternate Names:
Leukotoxin
Application:
(±)9(10)-EpOME is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst
CAS Number:
6814-52-4
Molecular Weight:
296.5
Molecular Formula:
C18H32O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
((±)9(10)-EpOME is a racemic epoxide derivative of linoleic acid, belonging to the class of epoxy fatty acids involved in cellular processes and signaling. The epoxide group is located between carbons 9 and 10 of the fatty acid chain, imparting distinct biochemical characteristics. These epoxy fatty acids are products of either enzymatic or spontaneous oxidation of linoleic acid and play a role in inflammation, vasodilation, and pain modulation.
(±)9(10)-EpOME (CAS 6814-52-4) References
- Role of Mannheimia haemolytica leukotoxin in the pathogenesis of bovine pneumonic pasteurellosis. | Jeyaseelan, S., et al. 2002. Anim Health Res Rev. 3: 69-82. PMID: 12665107
- Aggregatibacter actinomycetemcomitans leukotoxin: a powerful tool with capacity to cause imbalance in the host inflammatory response. | Johansson, A. 2011. Toxins (Basel). 3: 242-59. PMID: 22069708
- Mechanisms of LtxA (Leukotoxin), a Potent New Anti-Inflammatory Agent for the Treatment of Alopecia Areata. | Kachlany, SC. 2015. J Investig Dermatol Symp Proc. 17: 19-22. PMID: 26551939
- Three variants of the leukotoxin gene in human isolates of Fusobacterium necrophorum subspecies funduliforme. | Holm, K., et al. 2017. Anaerobe. 45: 129-132. PMID: 28330774
- Aggregatibacter (Actinobacillus) actimycetemcomitans leukotoxin and human periodontitis - A historic review with emphasis on JP2. | Tsai, CC., et al. 2018. Kaohsiung J Med Sci. 34: 186-193. PMID: 29655406
- Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA; Leukothera®): Mechanisms of Action and Therapeutic Applications. | Vega, BA., et al. 2019. Toxins (Basel). 11: PMID: 31454891
- Aggregatibacter actinomycetemcomitans leukotoxin: From mechanism to targeted anti-toxin therapeutics. | Krueger, E. and Brown, AC. 2020. Mol Oral Microbiol. 35: 85-105. PMID: 32061022
- Evaluation of the Virulence of Aggregatibacter actinomycetemcomitans Through the Analysis of Leukotoxin. | Nagasawa, T., et al. 2021. Methods Mol Biol. 2210: 185-193. PMID: 32815139
- Leukotoxin production by Fusobacterium necrophorum strains in relation to severity of liver abscesses in cattle. | Pillai, DK., et al. 2021. Anaerobe. 69: 102344. PMID: 33588043
- Epigallocatechin gallate alters leukotoxin secretion and Aggregatibacter actinomycetemcomitans virulence. | Chang, EH. and Brown, AC. 2021. J Pharm Pharmacol. 73: 505-514. PMID: 33793838
- Aggregatibacter actinomycetemcomitans Leukotoxin Activates the NLRP3 Inflammasome and Cell-to-Cell Communication. | Kelk, P., et al. 2022. Pathogens. 11: PMID: 35215102
- Computational modeling and druggability assessment of Aggregatibacter actinomycetemcomitans leukotoxin. | Hakmi, M., et al. 2022. Comput Methods Programs Biomed. 222: 106952. PMID: 35724475
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)9(10)-EpOME, 25 µg | sc-221169 | 25 µg | $76.00 | |||
(±)9(10)-EpOME, 50 µg | sc-221169A | 50 µg | $126.00 |