Date published: 2026-5-24

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(±)8(9)-EET Ethanolamide

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Molecular Weight:
363.5
Molecular Formula:
C22H37NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(±)8(9)-EET Ethanolamide is a synthetic derivative combining the properties of epoxyeicosatrienoic acids (EETs) with ethanolamide, designed to facilitate research into the biological effects and mechanisms of EETs. EETs, notably produced by the cytochrome P450-mediated metabolism of arachidonic acid, are critical regulators in various physiological processes, including vasodilation and inflammation modulation. The specific isomer, 8(9)-EET, plays a role in these processes, and by introducing an ethanolamide group, (±)8(9)-EET Ethanolamide exhibits potentially altered solubility and enhanced interaction capabilities with cellular components. This modification aims to enhance the compound′s utility in research by improving its handling and detection properties. In experimental settings, this molecule is primarily used to investigate how EETs interact within cellular environments, particularly focusing on their role in signaling pathways that control vascular functions and inflammatory responses. By studying (±)8(9)-EET Ethanolamide, researchers can gain insights into the localized effects of EETs on cellular signaling, offering a deeper understanding of their role in maintaining vascular homeostasis and modulating inflammatory processes. This research helps explain the complex network of lipid signaling in cell physiology and pathophysiology without direct implications for health condition management.


(±)8(9)-EET Ethanolamide References

  1. The fatty acid amide hydrolase (FAAH).  |  Deutsch, DG., et al. 2002. Prostaglandins Leukot Essent Fatty Acids. 66: 201-10. PMID: 12052036
  2. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.  |  Kozak, KR., et al. 2002. J Biol Chem. 277: 44877-85. PMID: 12244105
  3. The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.  |  Lambert, DM. and Fowler, CJ. 2005. J Med Chem. 48: 5059-87. PMID: 16078824
  4. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist.  |  Snider, NT., et al. 2009. Mol Pharmacol. 75: 965-72. PMID: 19171674
  5. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.  |  Katoh, T., et al. 1991. Am J Physiol. 261: F578-86. PMID: 1928373
  6. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.  |  Felder, CC., et al. 1993. Proc Natl Acad Sci U S A. 90: 7656-60. PMID: 8395053

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±)8(9)-EET Ethanolamide, 25 µg

sc-221159
25 µg
$86.00

(±)8(9)-EET Ethanolamide, 50 µg

sc-221159A
50 µg
$163.00