(±)8(9)-EET-d11
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8(9)-EET-d11 is a stable isotope-labeled analog of 8(9)-EET, a natural epoxyeicosatrienoic acid (EET) that is a metabolite of arachidonic acid. 8(9)-EET-d11 is used to investigate the metabolism, distribution, and biological activities of 8(9)-EET in various biological systems. It is utilized to study the mode of action of 8(9)-EET at the molecular and cellular levels, providing insights into its interactions with specific enzymes, receptors, and signaling pathways. Researchers can elucidate the metabolic fate of 8(9)-EET and its potential role in modulating physiological processes. This stable isotope-labeled analog allows for the precise quantification and tracking of 8(9)-EET in complex biological samples. 8(9)-EET-d11 serves as useful for understanding the biological functions and regulatory mechanisms associated with 8(9)-EET in experimental research applications.
(±)8(9)-EET-d11 References
- Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice. | Sodhi, K., et al. 2009. J Pharmacol Exp Ther. 331: 906-16. PMID: 19717790
- Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes. | Vanella, L., et al. 2011. Prostaglandins Other Lipid Mediat. 96: 54-62. PMID: 21821145
- Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin. | Burgess, AP., et al. 2012. Cell Physiol Biochem. 29: 99-110. PMID: 22415079
- EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice. | Cao, J., et al. 2017. Am J Physiol Heart Circ Physiol. 313: H368-H380. PMID: 28576832
- Chiral lipidomics of monoepoxy and monohydroxy metabolites derived from long-chain polyunsaturated fatty acids. | Blum, M., et al. 2019. J Lipid Res. 60: 135-148. PMID: 30409844
- Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth. | Cho, HJ., et al. 2020. Redox Biol. 29: 101405. PMID: 31926628
- Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery. | Hu, J., et al. 2021. Sci Rep. 11: 18764. PMID: 34548575
- Bone-Targeted Delivery of Novokinin as an Alternative Treatment Option for Rheumatoid Arthritis. | Ranjit, A., et al. 2022. Pharmaceutics. 14: PMID: 36015308
- Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia. | Feehan, KT., et al. 2024. Nat Commun. 15: 4326. PMID: 38773113
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)8(9)-EET-d11, 10 µg | sc-221161 | 10 µg | $150.00 | |||
(±)8(9)-EET-d11, 25 µg | sc-221161A | 25 µg | $482.00 |