(±)8-HETE (CAS 79495-84-4)

(±)8-HETE, identified by the CAS number 79495-84-4, is a racemic mixture of enantiomers of 8-hydroxyeicosatetraenoic acid, a biologically active metabolite of arachidonic acid. This compound is produced through the action of 8-lipoxygenase enzymes on arachidonic acid, a process that leads to the insertion of a hydroxyl group at the eighth carbon of the eicosatetraenoic acid chain. The presence of both enantiomers in the (±)8-HETE formulation allows for a broader investigation of the stereospecific activities of each form in research settings. (±)8-HETE is extensively studied for its role in modulating cellular functions through its interaction with various signaling pathways. It is particularly noted for its involvement in the regulation of ion transport across membranes and the modulation of protein kinase activities, which are critical for cell signaling and function. Researchers utilize (±)8-HETE to explore its effects on cell signaling mechanisms, particularly those related to the regulation of inflammatory processes and cellular response to oxidative stress. The insights gained from studying (±)8-HETE contribute significantly to understanding the complex roles of lipid mediators in cellular physiology and the complex network of signaling pathways that maintain cellular homeostasis and response to environmental stimuli.