(±)8,9-DHET (CAS 192461-96-4)
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(±)8,9-DHET is a compound of interest in various research sectors, particularly in the study of lipid metabolism and signaling pathways. In research applications, (±)8,9-DHET is often employed as a standard in the quantification of 8,9-EET, a cytochrome P450 epoxygenase metabolite of arachidonic acid, by chromatographic analysis. The compound plays a role in the investigation of the epoxide hydrolase pathway, which helps in understanding the biological functions of epoxyeicosatrienoic acids (EETs) and their metabolites in cellular signaling. Researchers have also utilized (±)8,9-DHET in the study of vascular biology, exploring its effects on blood vessels and its potential role in regulating blood pressure and vascular tone. Additionally, the compound is used in the examination of its involvement in inflammatory responses, helping to understand the complex cascade of lipid mediators in inflammatory processes.
(±)8,9-DHET (CAS 192461-96-4) References
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- Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs. | Sasaki, DM., et al. 2002. Adv Exp Med Biol. 507: 531-6. PMID: 12664636
- Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids. | Kirchheiner, J., et al. 2008. Pharmacogenomics. 9: 277-88. PMID: 18303964
- 20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. | Chen, Y., et al. 2011. Biochemistry. 50: 3840-8. PMID: 21469660
- A sensitive LC-MS/MS method for the quantification of regioisomers of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids in human plasma during endothelial stimulation. | Duflot, T., et al. 2017. Anal Bioanal Chem. 409: 1845-1855. PMID: 27981341
- Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis. | Valdes, AM., et al. 2018. J Lipid Res. 59: 1763-1770. PMID: 29986999
- Inula japonica ameliorated bleomycin-induced pulmonary fibrosis via inhibiting soluble epoxide hydrolase. | Zhao, WY., et al. 2020. Bioorg Chem. 102: 104065. PMID: 32663670
- Dihydroxyeicosatrienoic Acid, a Metabolite of Epoxyeicosatrienoic Acids Upregulates Endothelial Nitric Oxide Synthase Expression Through Transcription: Mechanism of Vascular Endothelial Function Protection. | Zuo, D., et al. 2021. Cell Biochem Biophys. 79: 289-299. PMID: 33811614
- CYP2J2-produced epoxyeicosatrienoic acids contribute to the ferroptosis resistance of pancreatic ductal adenocarcinoma in a PPARγ-dependent manner. | Tao, P., et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 46: 932-941. PMID: 34707002
- Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. | Oltman, CL., et al. 1998. Circ Res. 83: 932-9. PMID: 9797342
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)8,9-DHET, 25 µg | sc-221155 | 25 µg | $119.00 | |||
(±)8,9-DHET, 50 µg | sc-221155A | 50 µg | $293.00 |