Molecular structure of (±)-5′-Chloro-5′-deoxy-ENBA, CAS Number: 103626-26-2
(±)-5′-Chloro-5′-deoxy-ENBA (CAS 103626-26-2)
Alternate Names:
N-Bicyclo[2.2.1]hept-2-yl-5′-chloro-5′-deoxyadenosine
Application:
(±)-5′-Chloro-5′-deoxy-ENBA is a selective Adenosine A1-R agonist
CAS Number:
103626-26-2
Molecular Weight:
379.84
Molecular Formula:
C17H22CIN5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A highly selective adenosine A1 receptor agonist (Ki values are 0.51, 1290, 1340 and 2740 at A1, A3, A2A and A2B receptors respectively). Reverses formaline-induced nocifensive behavior in mice; antinociceptive.
(±)-5′-Chloro-5′-deoxy-ENBA (CAS 103626-26-2) References
- N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice. | Franchetti, P., et al. 2009. J Med Chem. 52: 2393-406. PMID: 19317449
- 5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions. | Luongo, L., et al. 2012. Molecules. 17: 13712-26. PMID: 23174891
- The A1 adenosine receptor as a new player in microglia physiology. | Luongo, L., et al. 2014. Glia. 62: 122-32. PMID: 24272707
- Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control. | Trusel, M., et al. 2015. Cell Rep. 13: 1353-1365. PMID: 26549453
- Adenosine effectively restores endotoxin-induced inhibition of human neutrophil chemotaxis via A1 receptor-p38 pathway. | Xu, X., et al. 2017. Inflamm Res. 66: 353-364. PMID: 28074216
- Tremorolytic effect of 5'-chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, evaluated in the harmaline-induced model in rats. | Kosmowska, B., et al. 2017. CNS Neurosci Ther. 23: 438-446. PMID: 28371468
- N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor. | Trivedi, BK., et al. 1989. J Med Chem. 32: 8-11. PMID: 2909748
- In Vivo Evaluation of A1 Adenosine Agonists as Novel Anticonvulsant Medical Countermeasures to Nerve Agent Intoxication in a Rat Soman Seizure Model. | Thomas, TP., et al. 2019. Neurotox Res. 36: 323-333. PMID: 31069755
- Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5'-Chloro-5'-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor. | Kosmowska, B., et al. 2020. Neuroscience. 429: 106-118. PMID: 31935489
- Extracellular AMP Suppresses Endotoxemia-Induced Inflammation by Alleviating Neutrophil Activation. | Hua, Y., et al. 2020. Front Immunol. 11: 1220. PMID: 32733440
- Anti-nociceptive effects of Sedum Lineare Thunb. on spared nerve injury-induced neuropathic pain by inhibiting TLR4/NF-κB signaling in the spinal cord in rats. | Wang, XY., et al. 2021. Biomed Pharmacother. 135: 111215. PMID: 33418303
- Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice. | Metzner, K., et al. 2021. Purinergic Signal. 17: 503-514. PMID: 34313915
- The role of adenosine receptor ligands on inflammatory pain: possible modulation of TRPV1 receptor function. | Haddad, M., et al. 2023. Inflammopharmacology. 31: 337-347. PMID: 36580157
Activator of:
Adenosine A1-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-5′-Chloro-5′-deoxy-ENBA, 10 mg | sc-291068 | 10 mg | $459.00 | |||
(±)-5′-Chloro-5′-deoxy-ENBA, 50 mg | sc-291068A | 50 mg | $1224.00 |