(+/-)-5prime-Chloro-5prime-deoxy-ENBA CAS: 103626-26-2
MF: C17H22CIN5O3
MW: 379.84
A selective Adenosine A1-R agonist.

(±)-5′-Chloro-5′-deoxy-ENBA (CAS 103626-26-2)

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Alternate Names: N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine
Application: (±)-5′-Chloro-5′-deoxy-ENBA is a selective Adenosine A1-R agonist
CAS Number: 103626-26-2
Molecular Weight: 379.84
Molecular Formula: C17H22CIN5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(±)-5′-Chloro-5′-deoxy-ENBA is a highly selective Adenosine A1-R agonist (Ki values are 0.51, 1290, 1340 and 2740 at Adenosine A1-R, Adenosine A3-R, Adenosine A2A-R and Adenosine A2B-R, respectively). (±)-5′-Chloro-5′-deoxy-ENBA is also an antinociceptive.


References

1. Trivedi, B.K, et al. 1989. J. Med. Chem. 32: 8-11. PMID: 2909748
2. Franchetti, P., et al. 2009. J. Med. Chem. 52: 2393-2406. PMID: 19317449

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), and DMSO (100 mM).
Storage :
Store at 4° C
Boiling Point :
~675.0° C at 760 mmHg (Predicted)
Density :
~1.9 g/cm3 (Predicted)
Ki Data :
A1 receptor: Ki= 0.51 nM (human); A3 receptor: Ki= 1.29 µM (human); A2A receptor: Ki= 1.34 µM (human); A2B receptor: Ki= 2.74 µM (human)
pK Values :
pKa: 13.03 (Predicted), pKb: 3.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
42636897
SMILES :
C1CC2CC1CC2NC3=NC=NC4=C3N=CN4[[email protected]]5[[email protected]@H]([[email protected]@H]([[email protected]](O5)CCl)O)O

Download SDS (MSDS)

Certificate of Analysis

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