Molecular structure of (±)5-iPF2α-VI, CAS Number: 180469-63-0
(±)5-iPF2α-VI (CAS 180469-63-0)
Application:
(±)5-iPF2α-VI is a minor isoprostane constituent able to form internal lactones
CAS Number:
180469-63-0
Purity:
>95%
Molecular Weight:
354.5
Molecular Formula:
C20H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
While the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes.2 Currently, the most extensively studied of these is 8-isoprostane (8-epi-PGF2α, iPF2α-III).3,4 8-isoprostane, however, is a minor isoprostane constituent when compared to some of the other isomers which form in natural conditions of oxidative stress.5 This class has been shown to be one of the major isoprostane products, in contrast to 8-isoprostane. In addition to being produced in greater abundance than 8-isoprostane, Type VI isoprostanes form internal lactones, which facilitates their extraction and purification from biological samples.5,6,7,8
(±)5-iPF2α-VI (CAS 180469-63-0) References
- A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. | Morrow, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 9383-7. PMID: 2123555
- A case series of the dynamics of lipid mediators in patients with sepsis. | Hamaguchi, M., et al. 2019. Acute Med Surg. 6: 413-418. PMID: 31592324
- Isoprostanes in wastewater as biomarkers of oxidative stress during COVID-19 pandemic. | Bowers, I. and Subedi, B. 2021. Chemosphere. 271: 129489. PMID: 33434819
- Simultaneous analyses of urinary eicosanoids and related mediators identified tetranor-prostaglandin E metabolite as a novel biomarker of diabetic nephropathy. | Morita, Y., et al. 2021. J Lipid Res. 62: 100120. PMID: 34560080
- Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis. | Tusa, NV., et al. 2022. J Vet Intern Med. 36: 1958-1965. PMID: 36086902
- Urinary lipid profile of patients with coronavirus diseases 2019. | Kida, M., et al. 2022. Front Med (Lausanne). 9: 941563. PMID: 36226145
- Prostaglandin Metabolome Profiles in Zebrafish (Danio rerio) Exposed to Acetochlor and Butachlor. | Wu, S., et al. 2023. Int J Mol Sci. 24: PMID: 36834899
- 8-Epi PGF2 alpha: specific analysis of an isoeicosanoid as an index of oxidant stress in vivo. | Delanty, N., et al. 1996. Br J Clin Pharmacol. 42: 15-9. PMID: 8807139
- Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat. | Waugh, RJ., et al. 1997. Free Radic Biol Med. 23: 943-54. PMID: 9378374
- Evidence for the formation of dinor isoprostanes E1 from alpha-linolenic acid in plants. | Parchmann, S. and Mueller, MJ. 1998. J Biol Chem. 273: 32650-5. PMID: 9830005
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)5-iPF2α-VI, 25 µg | sc-205138 | 25 µg | $184.00 | |||
(±)5-iPF2α-VI, 100 µg | sc-205138A | 100 µg | $667.00 |