Molecular structure of (±) 5-HETE Lactone, CAS Number: 73279-37-5
(±) 5-HETE Lactone (CAS 73279-37-5)
Application:
(±) 5-HETE Lactone is an inhibitor and marker of 5-LO activity
CAS Number:
73279-37-5
Molecular Weight:
302.5
Molecular Formula:
C20H30O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
(±) 5-HETE Lactone is a unique marker for 5-LO (5-lipoxygenase) activation. (±) 5-HETE Lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. It inhibits 5-LO (5-lipoxygenase) (IC50=27 µM) from rat basophilic leukemia cells. The lactone form is several times more potent.
(±) 5-HETE Lactone (CAS 73279-37-5) References
- Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones. | Connelly, PW., et al. 2011. Biochim Biophys Acta. 1811: 39-45. PMID: 21044894
- Evidence for 5-lipoxygenase activity in human B cell lines. A possible role for arachidonic acid metabolites during B cell signal transduction. | Schulam, PG. and Shearer, WT. 1990. J Immunol. 144: 2696-701. PMID: 2108210
- Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues. | Kerdesky, FA., et al. 1987. J Med Chem. 30: 1177-86. PMID: 3599023
Inhibitor of:
5-LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±) 5-HETE Lactone, 50 µg | sc-200957 | 50 µg | $101.00 | |||
(±) 5-HETE Lactone, 1 mg | sc-200957A | 1 mg | $1140.00 |