Molecular structure of (±)5,6-DHET, CAS Number: 213382-49-1
(±)5,6-DHET (CAS 213382-49-1)
Alternate Names:
(±)5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid; (±)5,6-DiHETrE; (±)5(6)-DiHET
CAS Number:
213382-49-1
Molecular Weight:
338.5
Molecular Formula:
C20H34O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)5,6-DHET acts as an epoxyeicosatrienoic acid (EET) metabolite. (±)5,6-DHET is formed from the metabolism of arachidonic acid by cytochrome P450 epoxygenases. It functions as a signaling molecule in various cellular processes, including the modulation of ion channels and the regulation of intracellular calcium levels. (±)5,6-DHET is also involved in the inhibition of platelet aggregation and the promotion of endothelial cell migration. Its mechanism of action involves binding to specific receptors and activating downstream signaling pathways, ultimately leading to the observed physiological effects.
(±)5,6-DHET (CAS 213382-49-1) References
- Hemodialysis and Plasma Oxylipin Biotransformation in Peripheral Tissue. | Liu, T., et al. 2022. Metabolites. 12: PMID: 35050156
- Determination of Lipoxygenase, CYP450, and Non-Enzymatic Metabolites of Arachidonic Acid in Essential Hypertension and Type 2 Diabetes. | Feugray, G., et al. 2022. Metabolites. 12: PMID: 36144261
- Modulations of bioactive lipids and their receptors in postmortem Alzheimer's disease brains. | Kurano, M., et al. 2022. Front Aging Neurosci. 14: 1066578. PMID: 36570536
- Relevance of PUFA-derived metabolites in seminal plasma to male infertility. | Chen, X., et al. 2023. Front Endocrinol (Lausanne). 14: 1138984. PMID: 37284213
- Circulating oxylipin and bile acid profiles of dexmedetomidine, propofol, sevoflurane, and S-ketamine: a randomised controlled trial using tandem mass spectrometry. | Nummela, A., et al. 2022. BJA Open. 4: 100114. PMID: 37588789
- Renin-Angiotensin System Components and Arachidonic Acid Metabolites as Biomarkers of COVID-19. | Ghimire, B., et al. 2023. Biomedicines. 11: PMID: 37626615
- Inflammation, lipid dysregulation, and transient receptor potential cation channel subfamily V member 4 signaling perpetuate chronic vulvar pain. | Bekauri, T., et al. 2024. Pain. 165: 820-837. PMID: 37889581
- Dietary Supplementation with Bupleuri Radix Reduces Oxidative Stress Occurring during Growth by Regulating Rumen Microbes and Metabolites. | Pan, C., et al. 2024. Animals (Basel). 14: PMID: 38540025
- Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer. | Zhang, Q., et al. 2024. Oncol Lett. 27: 209. PMID: 38549802
- Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity. | Hateley, C., et al. 2024. EBioMedicine. 103: 105127. PMID: 38677183
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)5,6-DHET, 25 µg | sc-221046 | 25 µg | $154.00 | |||
(±)5,6-DHET, 50 µg | sc-221046A | 50 µg | $294.00 |