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This is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer(1). It dose-dependently stimulates vasodilation of the rabbit kidney, where 18(S)-HETE does not affect perfusion pressure(2). 18-HETE has negligible effects on ATPase activity(2). At 1 µM this completely blocks 20-HETE-induced vasoconstriction of renal arterioles(3).
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)18-HETE, 25 µg | sc-220656 | 25 µg | $280.00 | |||
(±)18-HETE, 50 µg | sc-220656A | 50 µg | $342.00 |