Date published: 2026-5-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

(±)18-HEPE (CAS 141110-17-0)

0.0(0)
Write a reviewAsk a question

Alternate Names:
(±)-18-hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid
Application:
(±)18-HEPE is a compound produced by non-enzymatic oxidation of EPA
CAS Number:
141110-17-0
Purity:
≥97%
Molecular Weight:
318.5
Molecular Formula:
C20H30O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

(±)18-HEPE, cataloged under CAS number 141110-17-0, is a derivative of eicosapentaenoic acid (EPA), an essential omega-3 fatty acid that is abundant in marine oils. This compound includes both enantiomers of hydroxy-eicosapentaenoic acid with the hydroxyl group located at the eighteenth carbon. In the sphere of biochemical research, (±)18-HEPE is of particular interest for its role in modulating cellular and molecular pathways associated with inflammation. As a lipid mediator, it interacts with specific receptors and enzymes that are key in the regulation of inflammatory processes. These interactions can influence the production and function of cytokines and other signaling molecules, playing a crucial role in the orchestration of the body′s response to inflammation. Research involving (±)18-HEPE is primarily focused on understanding its influence on the synthesis of prostaglandins and leukotrienes, which are potent mediators of inflammation. By examining how (±)18-HEPE affects these pathways, scientists can gain valuable insights into the fundamental mechanisms by which omega-3 fatty acids can modulate inflammatory responses. These studies contribute to a broader understanding of the complex network of signaling pathways that govern cellular responses to environmental stimuli and help in elucidating how dietary components like omega-3 fatty acids can influence these processes.


(±)18-HEPE (CAS 141110-17-0) References

  1. Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice.  |  Rodriguez-Echevarria, R., et al. 2018. World J Gastroenterol. 24: 461-474. PMID: 29398867
  2. Differential distribution of eicosanoids and polyunsaturated fatty acids in the Penaeus monodon male reproductive tract and their effects on total sperm counts.  |  Yotbuntueng, P., et al. 2022. PLoS One. 17: e0275134. PMID: 36137117
  3. Detoxification Cytochrome P450s (CYPs) in Families 1-3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids.  |  Eccles, JA. and Baldwin, WS. 2022. Cells. 12: PMID: 36611876
  4. Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model.  |  Zhang, K., et al. 2023. Microbiol Spectr. 11: e0295522. PMID: 36700635

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±)18-HEPE, 25 µg

sc-205067
25 µg
$143.00

(±)18-HEPE, 100 µg

sc-205067A
100 µg
$693.00