Molecular structure of (±)14(15)-EET
(±)14(15)-EET
Alternate Names:
(±)14,15-DiHETrE
Application:
(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450
Purity:
≥98%
Molecular Weight:
320.5
Molecular Formula:
C20H32O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
14(15)-EET is a lipid signaling molecule that functions as an epoxygenase metabolite of arachidonic acid. It plays a role in regulating various physiological processes. 14(15)-EET acts as an endogenous agonist for certain G protein-coupled receptors, leading to the activation of intracellular signaling pathways. This activation can result in the modulation of ion channels, enzyme activity, and gene expression. At the cellular level, 14(15)-EET may influence smooth muscle cell proliferation and migration, as well as endothelial cell function. Its mechanism of action involves binding to specific receptors and initiating downstream signaling that ultimately impact cellular function and physiological responses.
(±)14(15)-EET References
- Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. | Nithipatikom, K., et al. 2006. Am J Physiol Heart Circ Physiol. 291: H537-42. PMID: 16473964
- Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids. | Bernstrom, K., et al. 1992. J Biol Chem. 267: 3686-90. PMID: 1740420
- EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells. | Jiang, JX., et al. 2015. PLoS One. 10: e0128278. PMID: 26035589
- 5,6-Δ-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation. | Levi-Rosenzvig, R., et al. 2017. Free Radic Biol Med. 103: 87-94. PMID: 28007573
- Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library. | Aoyagi, R., et al. 2017. J Lipid Res. 58: 2229-2237. PMID: 28874441
- Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling. | Deng, BQ., et al. 2017. Proc Natl Acad Sci U S A. 114: 12608-12613. PMID: 29109264
- Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. | Oltman, CL., et al. 1998. Circ Res. 83: 932-9. PMID: 9797342
Substrate of:
CYP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)14(15)-EET, 25 µg | sc-220610 | 25 µg | $74.00 | |||
(±)14(15)-EET, 50 µg | sc-220610A | 50 µg | $136.00 |