Date published: 2026-5-15

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(±)14(15)-EET-SI (CAS 218461-97-3)

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Alternate Names:
14,15-EpETrE-SI; 14(15)-EET-SI; 14(15)-EET-sulfonimide
Application:
(±)14(15)-EET-SI is a metabolically stable analog of 14(15)-EET
CAS Number:
218461-97-3
Molecular Weight:
397.57
Molecular Formula:
C21H35NO4S
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(±)14(15)-EET-SI, identified by the CAS number 218461-97-3, is a synthetic analogue of epoxyeicosatrienoic acids (EETs), which are metabolites typically derived from the cytochrome P450 oxidation of arachidonic acid. This particular compound is intriguing for its role in signaling pathways that regulate a variety of physiological processes. EETs, and by extension their analogues like (±)14(15)-EET-SI, are primarily recognized for their involvement in modulating the activity of ion channels and the expression of certain genes associated with cellular functions. The mechanism of action for (±)14(15)-EET-SI is believed to be centered around its interaction with specific intracellular sites that influence signaling cascades, potentially affecting mechanisms such as the release of secondary messengers. In research contexts, this chemical has been utilized in studies exploring the complex interplay between epoxygenated fatty acids and cellular signaling pathways. For example, it has been applied in experimental models to dissect the pathways through which EETs and their analogues modulate cellular responses to various stimuli, offering insights into the underlying biochemical landscapes of cells and contributing to a broader understanding of cellular physiology without direct implications on health or disease management.


(±)14(15)-EET-SI (CAS 218461-97-3) References

  1. 14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.  |  Gauthier, KM., et al. 2004. Pharmacol Res. 49: 515-24. PMID: 15026029
  2. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.  |  Chen, JK., et al. 1998. J Biol Chem. 273: 29254-61. PMID: 9786938

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±)14(15)-EET-SI, 25 µg

sc-205014
25 µg
$85.00

(±)14(15)-EET-SI, 50 µg

sc-205014A
50 µg
$162.00