(±)14,15-DiHETE

(±)14,15-DiHETE, designated by its CAS registry number, is a dihydroxy derivative of eicosatetraenoic acid (EET), an eicosanoid, which plays a critical role in the study of cellular signaling and lipid metabolism. This compound is particularly noted for its involvement in the enzymatic pathways where it is formed by the epoxidation of arachidonic acid followed by hydration. The presence of hydroxyl groups at the 14th and 15th positions significantly modifies its interaction with various cell membrane components and signaling receptors. In research settings, (±)14,15-DiHETE has been used to explore the regulation of intracellular signaling pathways associated with the regulation of vascular tone, platelet aggregation, and inflammation. The compound′s ability to act at the cellular level, influencing the dynamics of calcium ion channels and other signaling molecules, makes it a valuable tool in physiological studies. Researchers have employed (±)14,15-DiHETE to understand more about the complex interplay between different lipid mediators in the cell and their roles in cellular communication processes. These studies shed light on the broader implications of lipid signaling in maintaining cellular homeostasis and responding to environmental changes, providing insights into fundamental biological processes.