(±)13-HODE cholesteryl ester (CAS 167354-91-8)

(±)13-HODE cholesteryl ester, identified by the CAS number 167354-91-8, is a cholesteryl ester derivative of the racemic mixture of 13-hydroxyoctadecadienoic acid (13-HODE), itself a product of linoleic acid oxidation primarily by lipoxygenases. This compound integrates the biological activity of 13-HODE with the biophysical properties conferred by esterification with cholesterol, thus enhancing its affinity for lipid membranes. This modification plays a significant role in the compound′s function in cellular environments, particularly in the modulation of lipid raft architecture and dynamics within cell membranes. Research on (±)13-HODE cholesteryl ester focuses on its role in influencing membrane fluidity and permeability, which are crucial for the regulation of signaling pathways that depend on membrane lipid composition. Additionally, this compound is used in studies to understand how lipid modifications affect the distribution and function of membrane-associated proteins and receptors. By altering the lipid context around these proteins, (±)13-HODE cholesteryl ester can influence signal transduction processes, providing insights into the mechanisms through which lipid modifications can affect cellular communication and overall cellular behavior. This research is fundamental in biochemistry and cell biology, offering deeper understanding of lipid-mediated cellular regulation and the interplay between lipid metabolism and cell signaling.