(±)12-HETE (CAS 71030-37-0)

(±)12-HETE, catalogued under the CAS number 71030-37-0, encompasses a racemic mixture of 12-hydroxyeicosatetraenoic acid enantiomers. This lipid mediator is synthesized through the 12-lipoxygenase pathway from arachidonic acid, which introduces a hydroxyl group at the twelfth carbon of the eicosanoid. Both enantiomers in the (±)12-HETE mixture are actively studied for their roles in regulating cellular mechanisms, particularly in the modulation of inflammatory pathways, altering cell signaling, and affecting the migration and adhesion of cells. As a potent modulator of cellular activity, (±)12-HETE is extensively utilized in biochemical research to explain the complex interactions between lipid mediators and cellular signaling pathways. Its involvement in the complex dynamics of signal transduction processes helps in understanding how cells communicate and respond to various stimuli. Research with (±)12-HETE has been instrumental in uncovering the roles of lipoxygenase products in cellular functions, offering insights into the cellular mechanisms that govern pathological and physiological states. This compound′s interaction with specific receptors and enzymes within the signaling pathways provides a deeper understanding of the molecular mechanisms that underpin cell behavior and response in various biological contexts.