(±)11,12-Epoxyeicosa-5Z,8Z,14Z-trienoic acid (CAS 123931-40-8)

(±)11,12-Epoxyeicosa-5Z,8Z,14Z-trienoic acid is a significant bioactive lipid mediator that plays a vital role in regulating various physiological and pathological processes. This compound is produced through the enzymatic oxidation of arachidonic acid (AA) by cytochrome P450 epoxygenases, including CYP2J2, CYP2C8, CYP2C9, and CYP2C19. It belongs to the cytoprotective eicosanoid family, which encompasses epoxyeicosatrienoic acids (EETs) and their corresponding diols (DHETs). (±)11,12-Epoxyeicosa-5Z,8Z,14Z-trienoic acid contributes significantly to vasodilation, inflammation, and platelet aggregation. The mechanism of action of (±)11,12-Epoxyeicosa-5Z,8Z,14Z-trienoic acid is intricate and not fully comprehended. It is believed to activate several intracellular pathways, including the mitogen-activated protein kinase (MAPK) pathway and the phosphoinositide 3-kinase (PI3K) pathway. Additionally, (±)11,12-Epoxyeicosa-5Z,8Z,14Z-trienoic acid is thought to act on G-protein coupled receptors and the nuclear transcription factor NF-κB.