Date published: 2026-4-26

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(±)10-HDoHE (CAS 90780-50-0)

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Alternate Names:
(±)10-hydroxy-4Z,7Z,11E,13Z,16Z,19Z-docosahexaenoic acid
Application:
(±)10-HDoHE is an autoxidation product of DHA which may serve as a marker for oxidative stress
CAS Number:
90780-50-0
Molecular Weight:
344.49
Molecular Formula:
C22H32O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(±)10-HDoHE, bearing the CAS number 90780-50-0, is a hydroxylated derivative of docosahexaenoic acid (DHA), a vital omega-3 fatty acid predominantly found in marine oils. This compound is characterized by the presence of a hydroxyl group at the tenth carbon in its molecular structure, with the (±) notation indicating a racemic mixture of both enantiomers. Within the scope of biochemical research, (±)10-HDoHE is of significant interest due to its role as a lipid mediator capable of influencing various intracellular signaling pathways. Its mechanism of action revolves around its interactions with specific enzymes and cell receptors that are pivotal in regulating inflammatory responses at the molecular level. The presence of the hydroxyl group at the tenth carbon significantly affects its biological activity, particularly in how it modulates the production and activity of cytokines, eicosanoids, and other signaling molecules involved in cellular communication. Research involving (±)10-HDoHE primarily focuses on dissecting these interactions to understand the compound′s influence on lipid signaling pathways and inflammatory processes. This research is crucial for elucidating the broader roles of omega-3 fatty acid derivatives in cellular physiology and the regulation of cellular responses to external stimuli, providing insights that extend beyond basic nutritional understanding to the molecular dynamics of cell behavior.


(±)10-HDoHE (CAS 90780-50-0) References

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  2. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations.  |  Yu, M., et al. 2017. Int J Mol Sci. 18: PMID: 28287417
  3. Lipids, fatty acids and hydroxy-fatty acids of Euphausia pacifica.  |  Yamada, H., et al. 2017. Sci Rep. 7: 9944. PMID: 28855640
  4. Target lipidomics approach to reveal the resolution of inflammation induced by Chinese medicine combination in Liu-Shen-Wan against realgar overexposure to rats.  |  Wang, J., et al. 2020. J Ethnopharmacol. 249: 112171. PMID: 31442622
  5. Changes of tear lipid mediators after eyelid warming or thermopulsation treatment for meibomian gland dysfunction.  |  Ambaw, YA., et al. 2020. Prostaglandins Other Lipid Mediat. 151: 106474. PMID: 32783924
  6. Accumulation of polyunsaturated fatty acid-derived metabolites in the sarcopenic muscle of aging mice.  |  Kadoguchi, T., et al. 2023. Geriatr Gerontol Int. 23: 297-303. PMID: 36811314
  7. Oxidation of docosahexaenoic acid by rat liver microsomes.  |  VanRollins, M., et al. 1984. J Biol Chem. 259: 5776-83. PMID: 6232277
  8. Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate.  |  VanRollins, M. and Murphy, RC. 1984. J Lipid Res. 25: 507-17. PMID: 6234372
  9. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate.  |  Yamane, M., et al. 1994. J Chromatogr. 652: 123-36. PMID: 8006098
  10. Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by alpha-tocopherol-directed autoxidation.  |  Reynaud, D., et al. 1993. Anal Biochem. 214: 165-70. PMID: 8250220

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±)10-HDoHE, 25 µg

sc-204959
25 µg
$66.00

(±)10-HDoHE, 50 µg

sc-204959A
50 µg
$168.00