Molecular structure of Pleconaril
Pleconaril (CAS 153168-05-9)
Alternate Names:
3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; Picovir
Application:
Pleconaril is A picornavirus replication inhibitor
CAS Number:
153168-05-9
Molecular Weight:
381.35
Molecular Formula:
C18H18F3N3O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pleconaril is a picornavirus replication inhibitor. Specifically, it binds to the capsid proteins of a virus and prevents its RNA from being released into the cytoplasm of the host cell. This prevents the virus from replicating and spreading. Pleconaril may act to be effective in vitro against several human enteroviruses, including poliovirus, coxsackievirus, and echovirus. It is also active against other viruses, including rhinoviruses, herpes simplex virus, and respiratory syncytial virus. Additionally, Pleconaril has been used in laboratory experiments to study the antiviral activity of other compounds, such as ribavirin and amantadine.
Pleconaril (CAS 153168-05-9) References
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- Application of a VP4/VP2-inferred transmission clusters in estimating the impact of interventions on rhinovirus transmission. | Ng, KT., et al. 2022. Virol J. 19: 36. PMID: 35246187
- Fighting Enteroviral Infections to Prevent Type 1 Diabetes. | Nekoua, MP., et al. 2022. Microorganisms. 10: PMID: 35456818
- Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds. | Füzik, T., et al. 2022. J Virol. 96: e0060422. PMID: 35939401
- A patent review of pharmaceutical and therapeutic applications of oxadiazole derivatives for the treatment of chronic diseases (2013-2021). | Hassan, A., et al. 2022. Expert Opin Ther Pat. 32: 969-1001. PMID: 35993146
- Novel Synergistic Anti-Enteroviral Drug Combinations. | Ianevski, A., et al. 2022. Viruses. 14: PMID: 36146673
- Discovery and Optimization of Quinoline Analogues as Novel Potent Antivirals against Enterovirus D68. | Li, X., et al. 2022. J Med Chem. 65: 14792-14808. PMID: 36254462
- Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update. | Kainov, D. and Oksenych, V. 2022. Viruses. 14: PMID: 36298807
- Therapeutics for fulminant hepatitis caused by enteroviruses in neonates. | Wang, LC., et al. 2022. Front Pharmacol. 13: 1014823. PMID: 36339581
- Review on fluorinated nucleoside/non-nucleoside FDA-approved antiviral drugs. | Ismail, MMF. and Ayoup, MS. 2022. RSC Adv. 12: 31032-31045. PMID: 36348998
- Recent Advancement in Synthesis and Bioactivities of 1,3,4-Oxadiazole. | Chaudhary, T. and Upadhyay, PK. 2023. Curr Org Synth. 20: 663-677. PMID: 36453511
- Synthesis and antiviral activity of 1,2,3-triazolyl nucleoside analogues with N-acetyl-d-glucosamine residue. | Garifullin, BF., et al. 2023. Nucleosides Nucleotides Nucleic Acids. 1-23. PMID: 36960941
- Hand, Foot, and Mouth Disease Challenges and Its Antiviral Therapeutics. | Li, Z., et al. 2023. Vaccines (Basel). 11: PMID: 36992155
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pleconaril, 10 mg | sc-391701 | 10 mg | $326.00 |