Molecular structure of PLC Thio-PIP2 (sodium salt)
PLC Thio-PIP2 (sodium salt)
Alternate Names:
3-(3-(1,2-dihydroxy-1,2-dihexanoyl)thiopropane)inositol-4,5-diphosphate, trisodium salt
Application:
PLC Thio-PIP2 (sodium salt) is a thiol releasing analog of naturally occurring PIP2
Molecular Weight:
772.5
Molecular Formula:
C21H38O18P3S•3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PLC Thio-PIP2 (sodium salt) is an analog of naturally occurring PIP2 which contains sulfur instead of oxygen at the sn-3 position of the glycerol backbone. Phospholipase C (PLC) catalyzes the hydrolysis of phosphatidylinositol (4,5) bisphosphate (PIP2) on the cytoplasmic side of the cell membrane to yield diacylglycerol and inositol-1,4,5-triphosphate (IP3). This reaction initiates a well-known signal transduction pathway common to most cells. Hydrolysis by PLC yields a free thiol that reacts with chromogenic reagents such as DTNB (Ellman′s reagent) to allow quantitation of PLC activity.
PLC Thio-PIP2 (sodium salt) References
- Inositol phosphate biochemistry. | Majerus, PW. 1992. Annu Rev Biochem. 61: 225-50. PMID: 1323235
- Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. | Exton, JH. 1996. Annu Rev Pharmacol Toxicol. 36: 481-509. PMID: 8725399
- Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases. | Exton, JH. 1997. Eur J Biochem. 243: 10-20. PMID: 9030716
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PLC Thio-PIP2 (sodium salt), 100 µg | sc-224207 | 100 µg | $188.00 | |||
PLC Thio-PIP2 (sodium salt), 500 µg | sc-224207A | 500 µg | $846.00 |