PknG Inhibitor CAS: 329221-38-7
MF: C13H16N2O2S
MW: 264.3
A cell-permeable tetrahydrobenzothiophene compound.

PknG Inhibitor (CAS 329221-38-7)

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Alternate Names: Mycobacterial Protein Kinase G Inhibitor
Application: PknG Inhibitor is a cell-permeable tetrahydrobenzothiophene compound
CAS Number: 329221-38-7
Molecular Weight: 264.3
Molecular Formula: C13H16N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PknG Inhibitor is a cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCα, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10μM or higher) that does not otherwise affect the growth of BCG outside its infected host.


References

1. Walburger, Anne., et al., 2004. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science (New York, N.Y.). 304(5678): 1800-4. PMID: 15155913

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at 4° C
Melting Point :
213.11° C (Predicted)
Boiling Point :
465.32° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
PknG: IC50 = 0.39 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD00785286
SMILES :
C1CCC2=C(C1)C(=C(S2)NC(=O)C3CC3)C(=O)N

Download SDS (MSDS)

Certificate of Analysis

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PknG Inhibitor (CAS 329221-38-7)  Product Citations

See how others have used PknG Inhibitor (CAS 329221-38-7). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28237032  Chen, D. et al. 2017. Tuberculosis (Edinb). 103: 37-43.

Citations 1 to 1 of 1 total
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