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PKI (14-22) amide (myristoylated) (CAS 201422-03-9)

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Application:
PKI (14-22) amide (myristoylated) is a useful heat stable cAMP-dependent protein kinase inhibitor
CAS Number:
201422-03-9
Molecular Weight:
1209.5
Molecular Formula:
C53H100N20O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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PKI (14-22) amide (myristoylated) is a modified version of vasoactive intestinal peptide (VIP), a peptide hormone found naturally in the body. PKI (14-22) amide (myristoylated) is a useful heat stable PKA (cAMP-dependent protein kinase) inhibitor. This is often used to study PKA in cellular systems in-vitro. PKI (14-22) amide (myristoylated) consists of a 14-amino acid sequence with a myristoylated N-terminal amide, which enhances its stability, bioavailability, and effectiveness.


PKI (14-22) amide (myristoylated) (CAS 201422-03-9) References

  1. Physiological patterns of electrical stimulation can induce neuronal gene expression by activating N-type calcium channels.  |  Brosenitsch, TA. and Katz, DM. 2001. J Neurosci. 21: 2571-9. PMID: 11306610
  2. Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons.  |  Stern, CM., et al. 2011. Eur J Neurosci. 34: 671-81. PMID: 21819464
  3. An unsuspected property of natriuretic peptides: promotion of calcium-dependent catecholamine release via protein kinase G-mediated phosphodiesterase type 3 inhibition.  |  Chan, NY., et al. 2012. Circulation. 125: 298-307. PMID: 22158783
  4. cAMP protects acute promyelocytic leukemia cells from arsenic trioxide-induced caspase-3 activation and apoptosis.  |  Safa, M., et al. 2014. Eur J Pharmacol. 736: 115-23. PMID: 24815320
  5. β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.  |  Coutellier, L., et al. 2014. Ann Clin Transl Neurol. 1: 348-360. PMID: 24883337
  6. G protein-coupled estrogen receptor 1 mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP.  |  Yu, X., et al. 2014. Am J Physiol Endocrinol Metab. 307: E398-407. PMID: 25005496
  7. Cannabinoid signalling inhibits sarcoplasmic Ca2+ release and regulates excitation-contraction coupling in mammalian skeletal muscle.  |  Oláh, T., et al. 2016. J Physiol. 594: 7381-7398. PMID: 27641745
  8. Endogenous Gαq-Coupled Neuromodulator Receptors Activate Protein Kinase A.  |  Chen, Y., et al. 2017. Neuron. 96: 1070-1083.e5. PMID: 29154125
  9. Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy.  |  Yu, M., et al. 2018. J Exp Clin Cancer Res. 37: 114. PMID: 29866132
  10. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.  |  Hamnett, R., et al. 2019. Nat Commun. 10: 542. PMID: 30710088
  11. Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter.  |  Penton, D., et al. 2019. J Am Soc Nephrol. 30: 737-750. PMID: 30902838
  12. Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons.  |  Lahiri, AK. and Bevan, MD. 2020. Neuron. 106: 277-290.e6. PMID: 32075716
  13. Inhibitors of protein kinases A and C impair the motility of oncospheres of the model tapeworm Hymenolepis microstoma.  |  Preza, M., et al. 2021. Mol Biochem Parasitol. 246: 111423. PMID: 34562553

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PKI (14-22) amide (myristoylated), 0.5 mg

sc-471154
0.5 mg
$135.00