Molecular structure of PKG Inhibitor, CAS Number: 82801-73-8
PKG Inhibitor Inhibitor (CAS 82801-73-8)
See product citations (2)
Alternate Names:
arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid; [Ala32]-Histone H2B (29-35)
Application:
PKG Inhibitor is a specific cyclic GMP-dependent protein kinase (cGKI) inhibitor
CAS Number:
82801-73-8
Molecular Weight:
943.11
Molecular Formula:
C38H74N18O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PKG inhibitor is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum. NMDA potentiation and GABA nitric oxide depression have been reported to be blocked by the PKG inhibitor. Other PKG inhibitors include KT5823 (sc-3534), which activates apoptotic DNA fragmentation.
PKG Inhibitor Inhibitor (CAS 82801-73-8) References
- Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons. | Urushitani, M., et al. 2000. J Neurosci Res. 61: 443-8. PMID: 10931531
- A comparative study of laser spray and electrospray. | Kudaka, I., et al. 2000. Rapid Commun Mass Spectrom. 14: 1558-62. PMID: 10931553
- cGMP-induced presynaptic depression and postsynaptic facilitation at glutamatergic synapses in visual cortex. | Wei, JY., et al. 2002. Brain Res. 927: 42-54. PMID: 11814431
- Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. | Chan, SL. and Fiscus, RR. 2003. Mol Hum Reprod. 9: 775-83. PMID: 14614039
- Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor. | Diaz, CA., et al. 2006. Mol Biochem Parasitol. 146: 78-88. PMID: 16325279
- Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. | Pinkse, MWH., et al. 2009. J Biol Chem. 284: 16354-16368. PMID: 19369251
- Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors. | Glass, DB. 1983. Biochem J. 213: 159-64. PMID: 6615418
- Heat-stable inhibitor protein derived peptide substrate analogs: phosphorylation by cAMP-dependent and cGMP-dependent protein kinases. | Mitchell, RD., et al. 1995. Biochemistry. 34: 528-34. PMID: 7819246
- Role of cAMP in the reactivation of demembranated ram spermatozoa. | San Agustin, JT. and Witman, GB. 1994. Cell Motil Cytoskeleton. 27: 206-18. PMID: 8020107
- Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase. | Wexler, EM., et al. 1998. J Neurosci. 18: 2342-9. PMID: 9502795
Inhibitor of:
cGKI.Activator of:
Caldesmon.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PKG Inhibitor, 1 mg | sc-201161 | 1 mg | $81.00 |