Molecular structure of PKA Inhibitor IV, CAS Number: 99534-03-9
PKA Inhibitor IV (CAS 99534-03-9)
See product citations (17)
Alternate Names:
cAMP-dependent protein kinase inhibitor (5-24); PKI (5-24), PKA Inhibitor; TTYADFIASGRTGRRNAIHD
Application:
PKA Inhibitor IV is a peptide inhibitor for cAMP-dependent protein kinase (PKA)
CAS Number:
99534-03-9
Purity:
≥97% pure by HPLC
Molecular Weight:
2222.53
Molecular Formula:
C94H148N32O31
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PKA inhibitor substrate is a peptide inhibitor for cAMP-dependent protein kinase (PKA). it is a selective inhibitor (Ki ~2-8 nM) of PKA over other kinases; used at 500 nM to improve specificity of other kinase assays. Sequence corresponds to functional sequence mapping within the N-terminus domain of the cAMP protein kinase inhibitor.
PKA Inhibitor IV (CAS 99534-03-9) References
- Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. | Knighton, DR., et al. 1991. Science. 253: 414-20. PMID: 1862343
- Cloning, expression, solubilization, and purification of a functionally active recombinant cAMP-dependent protein kinase catalytic subunit-like protein PKAC1 from Trypanosoma equiperdum. | Guevara, A., et al. 2022. Protein Expr Purif. 192: 106041. PMID: 34953978
- A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. | Cheng, HC., et al. 1986. J Biol Chem. 261: 989-92. PMID: 3511044
- Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24). | Bossemeyer, D., et al. 1993. EMBO J. 12: 849-59. PMID: 8384554
- A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24). | Ruth, P., et al. 1996. Biol Chem. 377: 513-20. PMID: 8922286
- Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. | Narayana, N., et al. 1997. Biochemistry. 36: 4438-48. PMID: 9109651
Inhibitor of:
AKAP 82, Olfr1178, PKA, PKA Iα reg, PKA IIα reg, PKAα cat, PKAβ cat, and Ser/Thr Protein Kinase.Substrate of:
PKA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PKA Inhibitor IV, 0.5 mg | sc-3010 | 0.5 mg | $95.00 |