PKA IIα reg Antibody (Hs-36): sc-51630

PKA IIα reg Antibody (Hs-36) is a mouse monoclonal IgM antibody that detects PKA IIα in human samples through applications such as western blotting (WB) and immunofluorescence (IF). PKA IIα, a key component of the cAMP-dependent protein kinase (PKA) pathway, plays a crucial role in mediating cellular responses to various external signals, including those involved in cell proliferation, metabolism, and gene transcription. PKA IIα is primarily located in the cytoplasm and can translocate to the nucleus upon activation, where PKA IIα phosphorylates specific transcription factors, such as cAMP response element binding protein (CREB). PKA IIα′s ability to move to the nucleus is vital for function, as this movement allows for the regulation of gene expression in response to elevated cAMP levels. PKA IIα phosphorylation of CREB on serine 133 is a critical step that facilitates the recruitment of the transcriptional machinery, linking the signaling pathways to the transcription initiation complex. Anti-PKA IIα antibody (Hs-36) enables researchers to gain insights into the dynamics of the PKA signaling pathway and its implications in various physiological and pathological processes.

The preferred Intra-acrosomal protein antibody is Intra-acrosomal protein Antibody (Ds-2): sc-51659.