Molecular structure of Pizotifen malate, CAS Number: 5189-11-7
Pizotifen malate (CAS 5189-11-7)
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Alternate Names:
Pizotifan
Application:
Pizotifen malate is an antagonist of muscarinic receptors
CAS Number:
5189-11-7
Purity:
≥98%
Molecular Weight:
429.53
Molecular Formula:
C19H21NS•C4H6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pizotifen malate, a derivative of benzocycloheptathiophene, is a tricyclic compound found to be a potent inhibitor of SR-2 receptor activity. In addition, it has been found to display vasoconstrictor activity in vivo. Studies on mice suggest that Pizotifen malate may have embryotoxic effects due to decreased value of mitotic indices in bone marrow cells. Pizotifen malate has also been reported to have acute antagonistic affects on central muscarinic receptors.
Pizotifen malate (CAS 5189-11-7) References
- Solubility of solid dispersions of pizotifen malate and povidone. | Margarit, MV., et al. 2001. Drug Dev Ind Pharm. 27: 517-22. PMID: 11548858
- 5-HT2 receptor antagonists and migraine therapy. | Mylecharane, EJ. 1991. J Neurol. 238 Suppl 1: S45-52. PMID: 2045831
- Validation and application of reversed phase high-performance liquid chromatographic method for quantification of pizotifen malate in pharmaceutical solid dosage formulations. | Rahman, SM., et al. 2010. Pak J Pharm Sci. 23: 435-41. PMID: 20884459
- HPLC-UV analytical method for determination of pizotifen after in vitro transdermal diffusion studies. | Serna-Jiménez, CE., et al. 2012. Biomed Chromatogr. 26: 769-74. PMID: 22002332
- Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease. | Sarantos, MR., et al. 2012. J Huntingtons Dis. 1: 195-210. PMID: 23393546
- The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. | Lin, OA., et al. 2014. PLoS One. 9: e87026. PMID: 24466319
- Development of antimigraine transdermal delivery systems of pizotifen malate. | Serna-Jiménez, CE., et al. 2015. Int J Pharm. 492: 223-32. PMID: 26196273
- Antimigraine drug interactions with serotonin receptor subtypes in human brain. | Peroutka, SJ. 1988. Ann Neurol. 23: 500-4. PMID: 2898916
- Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. | Ujházy, E., et al. 1988. Agents Actions. 23: 376-8. PMID: 3394590
- Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma. | He, X., et al. 2023. Oncogene. 42: 1209-1223. PMID: 36841865
- Further evidence that prolactin secretion in adult female rats is differently modified after neonatal estrogenization or androgenization: responses to methysergide, quipazine, and pizotifen. | Collado, D. and Aguilar, E. 1993. Physiol Behav. 53: 161-5. PMID: 8434056
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SR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pizotifen malate, 100 mg | sc-201143 | 100 mg | $44.00 | |||
Pizotifen malate, 500 mg | sc-201143A | 500 mg | $222.00 |