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Pitavastatin Calcium (CAS 147526-32-7) - chemical structure image
Molecular structure of Pitavastatin Calcium, CAS Number: 147526-32-7
Pitavastatin Calcium (CAS 147526-32-7) - chemical structure image
Molecular structure of Pitavastatin Calcium, CAS Number: 147526-32-7
Molecular structure of Pitavastatin Calcium, CAS Number: 147526-32-7

Pitavastatin Calcium (CAS 147526-32-7)

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Alternate Names:
Pitavastatin hemicalcium; Nisvastatin
Application:
Pitavastatin Calcium is a competitive inhibitor of HMG-CoA reductase
CAS Number:
147526-32-7
Purity:
≥98%
Molecular Weight:
880.98
Molecular Formula:
C50H46CaF2N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Description
Technical Information
Safety Information
SDS & Certificate of Analysis

Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox (NADPH oxidase). In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187 (sc-3591). Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.


Pitavastatin Calcium (CAS 147526-32-7) References

  1. Pitavastatin (NK-104), a new HMG-CoA reductase inhibitor.  |  Isley, WL. 2001. Drugs Today (Barc). 37: 587-594. PMID: 12743630
  2. Pitavastatin inhibits upregulation of intermediate conductance calcium-activated potassium channels and coronary arteriolar remodeling induced by long-term blockade of nitric oxide synthesis.  |  Terata, Y., et al. 2003. Pharmacology. 68: 169-76. PMID: 12837970
  3. Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor.  |  Kajinami, K., et al. 2003. Cardiovasc Drug Rev. 21: 199-215. PMID: 12931254
  4. A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits.  |  Hayashi, T., et al. 2004. Atherosclerosis. 176: 255-63. PMID: 15380447
  5. Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor.  |  Takayama, T., et al. 2004. Circ J. 68: 1067-75. PMID: 15502390
  6. Estimation of pitavastatin calcium in tablet dosage forms by column liquid chromatography and ultraviolet spectrophotometry.  |  Panchal, HJ., et al. 2009. J AOAC Int. 92: 158-64. PMID: 19382574
  7. [Chiral separation of pitavastatin calcium enantiomers by capillary zone electrophoresis].  |  Cheng, X., et al. 2010. Se Pu. 28: 1089-93. PMID: 21381428
  8. Spectrophotometric Determination of Cefetamet Pivoxil Hydrochloride and Pitavastatin Calcium in Tablet Dosage form.  |  Vadia, NH., et al. 2008. Indian J Pharm Sci. 70: 649-51. PMID: 21394266
  9. The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia.  |  Yan, HM., et al. 2011. Expert Opin Pharmacother. 12: 1463-71. PMID: 21651447
  10. Simple LC-MS/MS methods for simultaneous determination of pitavastatin and its lactone metabolite in human plasma and urine involving a procedure for inhibiting the conversion of pitavastatin lactone to pitavastatin in plasma and its application to a pharmacokinetic study.  |  Qi, X., et al. 2013. J Pharm Biomed Anal. 72: 8-15. PMID: 23146221
  11. Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia.  |  Zhao, J., et al. 2015. J Zhejiang Univ Sci B. 16: 380-7. PMID: 25990055
  12. Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction.  |  Xiong, F., et al. 2015. Org Biomol Chem. 13: 9813-9. PMID: 26275074
  13. Therapeutic Arteriogenesis/Angiogenesis for Peripheral Arterial Disease by Nanoparticle-Mediated Delivery of Pitavastatin into Vascular Endothelial Cells.  |  Matsumoto, T., et al. 2020. Ann Vasc Dis. 13: 4-12. PMID: 32273916
  14. Simultaneous Determination of Telmisartan and Pitavastatin Calcium in Intestinal Perfusate by HPLC: Application to Intestinal Absorption Interaction Study.  |  Wang, J., et al. 2020. Pharm Nanotechnol. 8: 313-322. PMID: 32515316

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pitavastatin Calcium, 10 mg

sc-208176
10 mg
$112.00

Pitavastatin Calcium, 25 mg

sc-208176A
25 mg
$172.00

Can we use it as referance standard?

Asked by: BAHADIR
Thank you for your question. This biochemical, Pitavastatin Calcium | CAS 147526-32-7 (sc-208176), is provided as research grade. We are not able to provide any documentation certifying this as a reference standard.
Answered by: Tech Service
Date published: 2019-11-04

Could I ask how long could the Pitavastatin calcium powder keep stable in room temperature, Last time we bought a lot, and keep some of the power in -20 degree for several years, do you think it still works well? and how to store DMSO solution, thanks

Asked by: zhihua
Thank you for your question. It is okay to store sc-208176 at -20ºC. Storing at -20ºC may prolong the shelf life. It is recommended to retest the chemical before use after 1 year. It is also recommended to use solutions the same day they are made. If solutions need to be stored, we recommend to aliquot and freeze it. If stored in this way, solutions should be used within one month and multiple freeze/thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2019-03-15

dear SIr/ Madam, I want to by pitavastatin ( original form not salt form), so do your company sell it? i am loooking forward to your reply soon. Thank you very much

Asked by: MAI THI PHUONG
Thank you for your question. Unfortunately, we do not offer non-salt form of Pitavastatin.
Answered by: Technical Support
Date published: 2017-11-09

I bought pitavastatin. But I did not have solubility in the datasheet. Can I dissolve in DMSO? Can I make the stock concentration 50 ~ 100mM?

Asked by: spring
Thank you for your question. Pitavastatin Calcium (CAS 147526-32-7) is soluble in DMSO at 51 mg/mL (57.89 mM).
Answered by: Technical Support
Date published: 2017-02-04

Is it possible to store this compound in -18°C when it is diluted into methanol?

Asked by: two2igm05
Thank you for your question. We recommend storing it as -80 degrees Celsius after re-suspension, and using it within 6 months. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-19
  • y_2025, m_8, d_27, h_5CST
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Rated 5 out of 5 by from The chemical works well in our animal studiesThe chemical works well in our animal studies, will order again.
Date published: 2015-10-12
Rated 5 out of 5 by from ShibasakiShibasaki, M. et al. (PubMed 26367531) found that Pitavastatin (Pitavastatin hemicalcium; Nisvastatin), a competitive inhibitor of HMG-CoA reductase, reduced inflammation in atherosclerotic plaques in apolipoprotein E-deficient mice with late stage renal disease. -SCBT Publication Review
Date published: 2015-03-04
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Pitavastatin Calcium | CAS 147526-32-7 is rated 5.0 out of 5 by 2.
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