Molecular structure of Piribedil maleate salt
Piribedil maleate salt
Application:
Piribedil maleate salt is a dopamine agonist with selectivity for the D3 receptor subtype
Molecular Weight:
414.41
Molecular Formula:
C20H22N4O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Piribedil maleate is a derivative of Piribedil. Piribedil is a dopamine agonist reported to have selectivity for D3 subtype receptors with moderate to non-significant affinity for D2 and D1 receptors. As an atypical dopamine agonist reported to dose-dependently increase locomotor activity in rats and may be due to an indirect mode of action. Prirbedil is also not reported to cause release or inhibition of tritium-labeled dopamine uptake in synaptosomes obtained from rat nucleus accumbens. Additionally, Piribedil is reported to have an in vitro affinity to dopamine D3 receptor subtypes as evidenced by receptor binding autoradiography.
Piribedil maleate salt References
- Parkinson's disease: pathological mechanisms and actions of piribedil. | Jenner, P. 1992. J Neurol. 239 Suppl 1: S2-8. PMID: 1634907
- Identification of amino acid determinants of dopamine 2 receptor synthetic agonist function. | Al-Fulaij, MA., et al. 2007. J Pharmacol Exp Ther. 321: 298-307. PMID: 17204745
- Pharmacological analysis of human D1 AND D2 dopamine receptor missense variants. | Al-Fulaij, MA., et al. 2008. J Mol Neurosci. 34: 211-23. PMID: 18210231
- A comparative study of the locomotor activity effects of apomorphine and the 'atypical dopamine agonists' (piribedil and S3608). | Offermeier, J. and van Rooyen, JM. 1986. Life Sci. 38: 895-903. PMID: 3081774
- Profile of androgen receptor activators identified using high-throughput screen. | Itsumi, M., et al. 2021. Andrologia. 53: e13856. PMID: 33079406
- A reactive oxygen species Ca2+ signalling pathway identified from a chemical screen for modifiers of sugar-activated circadian gene expression. | Li, X., et al. 2022. New Phytol. 236: 1027-1041. PMID: 35842791
- In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic study. | Cagnotto, A., et al. 1996. Eur J Pharmacol. 313: 63-7. PMID: 8905329
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Piribedil maleate salt, 10 mg | sc-301552 | 10 mg | $117.00 |