Molecular structure of Pirarubicin, CAS Number: 72496-41-4
Pirarubicin (CAS 72496-41-4)
Application:
Pirarubicin is an anti-neoplastic and inhibitor of Topo II
CAS Number:
72496-41-4
Molecular Weight:
627.64
Molecular Formula:
C32H37NO12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pirarubicin is a chemical compound that finds its application in the field of biochemistry and molecular biology, particularly in the study of DNA interactions and cellular processes. It is known to intercalate into DNA, thereby interrupting the replication and transcription of genetic material. In the laboratory, pirarubicin is utilized to understand the mechanisms of DNA intercalation and the subsequent effects on cell proliferation. Researchers use this compound to investigate the cellular response to DNA damage and to elucidate the pathways involved in cell cycle regulation and apoptosis. Additionally, pirarubicin is a useful tool for studying the efficacy and specificity of chemical-DNA binding, which is of interest for designing molecules with high target affinity.
Pirarubicin (CAS 72496-41-4) References
- Membrane transport and antitumor activity of pirarubicin, and comparison with those of doxorubicin. | Sugiyama, T., et al. 1999. Jpn J Cancer Res. 90: 775-80. PMID: 10470291
- Pirarubicin versus doxorubicin in neoadjuvant/adjuvant chemotherapy for stage IIB limb high-grade osteosarcoma: does the analog matter? | Yu, W., et al. 2015. Med Oncol. 32: 307. PMID: 25432694
- Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. | Li, K., et al. 2015. Biochem Biophys Res Commun. 460: 380-5. PMID: 25791481
- Pirarubicin, an Anthracycline Anticancer Agent, Induces Apoptosis Through Generation of Hydrogen Peroxide. | Mizutani, H., et al. 2017. Anticancer Res. 37: 6063-6069. PMID: 29061786
- Oxidative DNA Damage Induced by Pirarubicin, an Anthracycline Anticancer Agent, in the Presence of Copper(II). | Mizutani, H., et al. 2018. Anticancer Res. 38: 2643-2648. PMID: 29715084
- RIPK1 Inhibition Enhances Pirarubicin Cytotoxic Efficacy through AKT-P21-dependent Pathway in Hepatocellular Carcinoma. | Huang, H., et al. 2018. Int J Med Sci. 15: 1648-1657. PMID: 30588188
- Efficacy of pirarubicin for nonmuscle invasive bladder cancer: A protocol of systematic review and meta-analysis. | Chen, DY., et al. 2020. Medicine (Baltimore). 99: e20415. PMID: 32501988
- Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway. | Qin, M., et al. 2021. J Biochem Mol Toxicol. 35: e22615. PMID: 32864822
- Qishen Huanwu capsule reduces pirarubicin-induced cardiotoxicity in rats by activating the PI3K/Akt/mTOR pathway. | Wang, F., et al. 2020. Ann Palliat Med. 9: 3453-3461. PMID: 33065796
- Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles. | Eskandari, Z., et al. 2021. Eur J Pharm Sci. 162: 105830. PMID: 33819623
- Gallic acid enhances pirarubicin‑induced anticancer in living K562 and K562/Dox leukemia cancer cells through cellular energetic state impairment and P‑glycoprotein inhibition. | Aye, KT., et al. 2021. Oncol Rep. 46: PMID: 34476509
- Molecular classification of patients with NMIBC predicts the efficacy of intravesical chemotherapy with pirarubicin, pharmorubicin and gemcitabine-immunohistochemistry-based classification. | Wang, T., et al. 2022. Jpn J Clin Oncol. 52: 642-649. PMID: 35348732
- Development and evaluation of PLA based hybrid block copolymeric nanoparticles for systemic delivery of pirarubicin as an anti-cancer agent. | Anees, M., et al. 2022. Int J Pharm. 620: 121761. PMID: 35472512
- Ring finger protein 10 improves pirarubicin-induced cardiac inflammation by regulating the AP-1/Meox2 signaling pathway. | Duan, L., et al. 2023. Toxicol Appl Pharmacol. 462: 116411. PMID: 36740146
Inhibitor of:
Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pirarubicin, 5 mg | sc-205810 | 5 mg | $170.00 | |||
Pirarubicin, 10 mg | sc-205810A | 10 mg | $300.00 |