Date published: 2025-10-2

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PIPPS (CAS 5625-56-9)

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Alternate Names:
PIPPS is also known as 1,4-Piperazinedipropanesulfonic acid, and Piperazine-N,N′-bis(3-propanesulfonic Acid)
Application:
PIPPS is a zwitterionic non-metal complexing buffer with no interference at wavelengths longer than 240 nm.
CAS Number:
5625-56-9
Purity:
≥97%
Molecular Weight:
330.40
Molecular Formula:
C10H22N2O6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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PIPPS, also known as Piperazine-N,N′-bis(3-propanesulfonic Acid, is a zwitterionic non-metal complexing buffer. PIPPS has mixed-mode dissociation constants of pKa1 = 3.73 and pKa2 = 7.96 (100 mM, 25°C). It has no interference at wavelengths longer than 240 nm. Its used in a wide range of applications, including electrophoresis, chromatography, and enzyme assays.


PIPPS (CAS 5625-56-9) References

  1. First hydrolysis constants of hexaaquacobalt(III) and -manganese(III): longstanding issues resolved.  |  Sisley, MJ. and Jordan, RB. 2006. Inorg Chem. 45: 10758-63. PMID: 17173433
  2. Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.  |  Wang, H., et al. 2015. Biochemistry. 54: 6462-74. PMID: 26422458
  3. Expression of Two Novel β-Glucosidases from Chaetomium atrobrunneum in Trichoderma reesei and Characterization of the Heterologous Protein Products.  |  Colabardini, AC., et al. 2016. Mol Biotechnol. 58: 821-831. PMID: 27714589
  4. Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.  |  Gu, C., et al. 2016. PLoS One. 11: e0165286. PMID: 27788189
  5. A novel multi-reaction model for kinetics of Zn release from soils: Roles of soil binding sites.  |  Peng, L., et al. 2018. J Colloid Interface Sci. 514: 146-155. PMID: 29248816
  6. Effects of Good's Buffers and pH on the Structural Transformation of Zero Valent Iron and the Oxidative Degradation of Contaminants.  |  He, C., et al. 2018. Environ Sci Technol. 52: 1393-1403. PMID: 29307183
  7. Spectrally decomposed dark-to-light transitions in Synechocystis sp. PCC 6803.  |  Acuña, AM., et al. 2018. Photosynth Res. 137: 307-320. PMID: 29600442
  8. The Effect of pH and Biogenic Ligands on the Weathering of Chrysotile Asbestos: The Pivotal Role of Tetrahedral Fe in Dissolution Kinetics and Radical Formation.  |  Walter, M., et al. 2019. Chemistry. 25: 3286-3300. PMID: 30417458
  9. Single-Molecule Force Spectroscopy Study on Modular Resilin Fusion Protein.  |  Griffo, A., et al. 2017. ACS Omega. 2: 6906-6915. PMID: 31457277
  10. Engineering marine fungi for conversion of D-galacturonic acid to mucic acid.  |  Vidgren, V., et al. 2020. Microb Cell Fact. 19: 156. PMID: 32736636
  11. The Potential Contribution of Hexavalent Chromium to the Carcinogenicity of Chrysotile Asbestos.  |  Walter, M., et al. 2022. Chem Res Toxicol. 35: 2335-2347. PMID: 36410050
  12. Avoiding interferences from Good's buffers: A contiguous series of noncomplexing tertiary amine buffers covering the entire range of pH 3-11.  |  Yu, Q., et al. 1997. Anal Biochem. 253: 50-6. PMID: 9356141

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PIPPS, 5 g

sc-204195C
5 g
$66.00

PIPPS, 25 g

sc-204195D
25 g
$206.00

PIPPS, 100 g

sc-204195
100 g
$612.00

PIPPS, 250 g

sc-204195A
250 g
$1224.00

PIPPS, 1 kg

sc-204195B
1 kg
$3570.00