PIPK II Antibody (D-3): sc-393246

PIPK II Antibody (D-3) is a mouse monoclonal IgM antibody that detects PIPK II protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-PIPK II antibody (D-3) is available as the non-conjugated form. PIPK II plays a crucial role in synthesizing phosphatidylinositol-4,5-bisphosphate, a lipid vital for various cellular processes, including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. PIPK II is predominantly located in the brain, where PIPK II contributes to neuronal signaling and synaptic function, highlighting PIPK II′s importance in neurobiology and potential implications in neurological disorders. The PIPK family is classified into three types, with type II PIPKs, including PIPK II α and β, being particularly significant due to their high expression levels in the central nervous system. PIPK II contains an activation loop that determines enzymatic specificity and subcellular targeting, making PIPK II essential for precise cellular signaling. By regulating phosphatidylinositol-4,5-bisphosphate production, PIPK II serves as a key messenger in signal transduction pathways, underscoring PIPK II′s importance in maintaining cellular homeostasis and responding to extracellular signals.

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PIPK II Antibody (D-3) References:

1. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.  |  Carricaburu, V., et al. 2003. Proc Natl Acad Sci U S A. 100: 9867-72. PMID: 12897244
2. Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1.  |  Cabezas, A., et al. 2006. Gene. 371: 34-41. PMID: 16448788
3. The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.  |  Rutherford, AC., et al. 2006. J Cell Sci. 119: 3944-57. PMID: 16954148
4. Type II PtdInsP kinases: location, regulation and function.  |  Clarke, JH., et al. 2007. Biochem Soc Symp. 149-59. PMID: 17233588
5. Enzymes phosphorylating lipids and polysaccharides.  |  Karataeva, NA. and Nevinsky, GA. 2007. Biochemistry (Mosc). 72: 367-79. PMID: 17511601
6. The phosphoinositide kinase PIP5K that produces the versatile signaling phospholipid PI4,5P(2).  |  Kanaho, Y., et al. 2007. Biol Pharm Bull. 30: 1605-9. PMID: 17827707
7. Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells.  |  Weixel, KM., et al. 2007. J Biol Chem. 282: 36534-42. PMID: 17940289
8. Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades.  |  Sinha, RK. and Subrahmanyam, G. 2007. Indian J Biochem Biophys. 44: 289-94. PMID: 18341203
9. Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.  |  Nelson, CD., et al. 2008. J Biol Chem. 283: 21093-101. PMID: 18534983

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PIPK II Antibody (D-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PIPK II Antibody (D-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PIPK II Antibody (D-3) Specifications

Alternate Product Name: PIPK II

Product Clone Name: D-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 2-27

Epitope Target: PIPK II

Epitope Species: human

Product Reactivity/Detection: PIPK II α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PIPK II Antibody (D-3): P: Blocking Peptide