Date published: 2025-12-5

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Piperonylamine (CAS 2620-50-0)

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Alternate Names:
1,3-Benzodioxole-5-methylamine; 3,4-(Methylenedioxy)benzylamine
CAS Number:
2620-50-0
Molecular Weight:
151.16
Molecular Formula:
C8H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Piperonylamine, also referred to as 4-hydroxy-3-methoxybenzylamine or 4-hydroxy-3-methoxybenzaldehyde, is a natural compound that has served as useful in scientific research for many years. Notably, it serves as a key building block in the synthesis of various drugs, vitamins, and other compounds, making it an essential intermediate. Moreover, piperonylamine contributes to the production of enzymes, hormones, and other vital biochemicals. While the precise mechanism of action of piperonylamine remains incompletely elucidated, current understanding suggests its function as a competitive inhibitor of specific enzymes involved in drug and compound metabolism.


Piperonylamine (CAS 2620-50-0) References

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  4. Enantioselective allylation of imines catalyzed by newly developed (-)-β-pinene-based π-allylpalladium catalyst: an efficient synthesis of (R)-α-propylpiperonylamine and (R)-pipecolic acid.  |  Fernandes, RA. and Nallasivam, JL. 2012. Org Biomol Chem. 10: 7789-800. PMID: 22910971
  5. RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-7 breast cancer cells.  |  de-Sá-Júnior, PL., et al. 2013. Toxicol Appl Pharmacol. 266: 385-98. PMID: 23238560
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  8. A Two-Step Procedure for the Overall Transamidation of 8-Aminoquinoline Amides Proceeding via the Intermediate N-Acyl-Boc-Carbamates.  |  Verho, O., et al. 2018. J Org Chem. 83: 4464-4476. PMID: 29578345
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  12. A short microwave-assisted synthesis of tetrahydroisoquinolin-pyrrolopyridinones by a triple process: Ugi-3CR–aza Diels–Alder/S-oxidation/Pummerer  |  Alejandro Islas-Jácome a, Eduardo González-Zamora a, Rocío Gámez-Montaño b. 2011. Tetrahedron Letters. 52: 245-5248.
  13. Heterogeneous copper-catalyzed coupling of amines: a possible way for the preparation of imines  |  Ágnes Magyar & Zoltán Hell. 2016. Monatshefte für Chemie - Chemical Monthly. 147: 1583–1589.
  14. Reactions of 2,3-dichloro-1,4-naphthoquinone with piperidine, amine and some thiol nucleophile  |  Abubaker Patan, F. Serpil Göksel & Sibel Sahinler Ayla. 2021. Phosphorus, Sulfur, and Silicon and the Related Elements. 196: 647-655.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Piperonylamine, 25 g

sc-250731
25 g
$138.00