Molecular structure of Pinacidil monohydrate, CAS Number: 85371-64-8
Pinacidil monohydrate (CAS 85371-64-8)
See product citations (6)
Alternate Names:
(±)-N-Cyano-N′-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate
Application:
Pinacidil monohydrate is a K+ channel activator
CAS Number:
85371-64-8
Purity:
≥98%
Molecular Weight:
263.34
Molecular Formula:
C13H19N5•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pinacidil is a K+ channel opener. Pinacidil is demonstrated to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. This action is suppressed by the ATP-dependent K+ (KATP) channel blockers Glibenclamide (sc-200982) and Tetrapentylammonium salts (sc-251210), suggesting that relaxations induced by Pinacidil are mediated by opening of KATP channels.
Pinacidil monohydrate (CAS 85371-64-8) References
- Drug release kinetics from polymeric films containing propranolol hydrochloride for transdermal use. | Rao, PR., et al. 2000. Pharm Dev Technol. 5: 465-72. PMID: 11109246
- Monolithic matrix type transdermal drug delivery systems of pinacidil monohydrate: in vitro characterisation. | Aqil, M. and Ali, A. 2002. Eur J Pharm Biopharm. 54: 161-4. PMID: 12191687
- Fabrication and evaluation of polymeric films for transdermal delivery of pinacidil. | Aqil, M., et al. 2004. Pharmazie. 59: 631-5. PMID: 15378854
- Role of ATP-dependent potassium channels in pulmonary vascular tone of fetal lambs with congenital diaphragmatic hernia. | de Buys Roessingh, AS., et al. 2006. Pediatr Res. 60: 537-42. PMID: 16988185
- The effect of potassium channel opener pinacidil on the non-pregnant rat uterus. | Novakovic, R., et al. 2007. Basic Clin Pharmacol Toxicol. 101: 181-6. PMID: 17697038
- The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase. | Sodi, R., et al. 2009. Clin Biochem. 42: 813-8. PMID: 19232334
- Modelling the long QT syndrome with induced pluripotent stem cells. | Itzhaki, I., et al. 2011. Nature. 471: 225-9. PMID: 21240260
- The sGC activator BAY 60-2770 has potent erectile activity in the rat. | Lasker, GF., et al. 2013. Am J Physiol Heart Circ Physiol. 304: H1670-9. PMID: 23585129
- Aggressive long-term antihypertensive therapy with pinacidil does not cause regression of cardiovascular hypertrophy in the spontaneously hypertensive rat. | Jespersen, LT., et al. 1986. J Hypertens. 4: 223-7. PMID: 2940293
- Effects of regular exercise on ventricular myocyte biomechanics and KATP channel function. | Wang, X. and Fitts, RH. 2018. Am J Physiol Heart Circ Physiol. 315: H885-H896. PMID: 30074836
- Pinacidil inhibits insulin release by increasing K+ outflow from pancreatic B-cells. | Lebrun, P., et al. 1988. Eur J Pharmacol. 156: 283-6. PMID: 3071468
- Transcending the Cutaneous Barrier Through Nanocarrier Exploration for Passive Delivery of Anti-hypertensive Drugs: A Critical Review. | Kumar, L. and Utreja, P. 2020. Recent Pat Nanotechnol. 14: 193-209. PMID: 32427090
- Metabolism of the new antihypertensive agent pinacidil in rat, dog and man. | Eilertsen, E., et al. 1982. Xenobiotica. 12: 187-96. PMID: 7113255
- Studies on vasorelaxation by tetrapentylammonium ions in rat aortic rings. | Huang, Y. 1997. Life Sci. 61: 1811-7. PMID: 9365228
Inhibitor of:
KCNRG, and SUR1.Activator of:
KCNE1L, KCNH5, KCNV1, KIR6.2, KRCC1, MaxiKα, MaxiKβ, Potassium Chloride, Shaker, and TASK-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pinacidil monohydrate, 10 mg | sc-203198 | 10 mg | $50.00 | |||
Pinacidil monohydrate, 50 mg | sc-203198A | 50 mg | $93.00 |