Pin1 Antibody (E-5): sc-365028
- Pin1 Antibody (E-5) is a mouse monoclonal IgG3 provided at 200 µg/ml
- specific for an epitope mapping between amino acids 116-146 near the C-terminus of Pin1 of human origin
- recommended for detection of Pin1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See Pin1 (G-8): sc-46660 for Pin1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pin1 Antibody (E-5). This work is in progress.
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Pin1 Antibody (E-5) is a mouse monoclonal IgG3 antibody designed to detect Pin1, also known as peptidylprolyl cis/trans isomerase NIMA-interacting 1. Anti-Pin1 antibody (E-5) targets an epitope mapping between amino acids 116-146 near the C-terminus of human Pin1, ensuring precise and reliable binding. Pin1 is a critical enzyme that facilitates the cis/trans isomerization of phosphorylated serine/threonine-proline motifs, a post-translational modification essential for the regulation of protein function, stability, and interaction within various signaling pathways. These modifications are pivotal for controlling key cellular processes such as cell cycle progression, apoptosis, and transcription, making Pin1 integral to maintaining cellular homeostasis and implicated in diseases like cancer and neurodegenerative disorders. The structural configuration of Pin1, comprising a WW domain and a PPIase domain, allows recognition and modification of specific phosphorylated substrates, thereby influencing conformational states and biological activities. Pin1 monoclonal antibody (E-5) exhibits broad species reactivity, effectively detecting Pin1 from mouse, rat, human, as well as additional species including equine, canine, bovine, and porcine origins, and is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. The high specificity and versatility of anti-Pin1 antibody (E-5) make this reagent an indispensable tool for researchers studying the intricate roles of Pin1′s post-translational modifications in various cellular contexts. By enabling detailed investigations into the regulation and function of Pin1, Pin1 (E-5) antibody supports advancements in understanding Pin1′s contribution to essential biological processes and potential as a therapeutic target in related diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pin1 Antibody (E-5) | sc-365028 | 200 µg/ml | $316.00 | |||
Pin1 (E-5) Neutralizing Peptide | sc-365028 P | 100 µg/0.5 ml | $68.00 |