Molecular structure of Pimelic Diphenylamide 106, CAS Number: 937039-45-7
Pimelic Diphenylamide 106 (CAS 937039-45-7)
Alternate Names:
TC-H 106; Histone Deacetylase Inhibitor VII
Application:
Pimelic Diphenylamide 106 is an HDAC1, HDAC2, HDAC3, and HDAC8 inhibitor
CAS Number:
937039-45-7
Molecular Weight:
339.43
Molecular Formula:
C20H25N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases). With prolonged preincubation (1-3 hours), pimelic diphenylamide inhibits the class I HDAC1, HDAC2, HDAC3, and HDAC8 (IC50 = 150, 760, 370, and 5,000 nM, respectively) but not the class II HDAC4, HDAC5, and HDAC7 (IC50 > 180 muM).
Pimelic Diphenylamide 106 (CAS 937039-45-7) References
- Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. | Chou, CJ., et al. 2008. J Biol Chem. 283: 35402-9. PMID: 18953021
- Drug-target residence time: critical information for lead optimization. | Lu, H. and Tonge, PJ. 2010. Curr Opin Chem Biol. 14: 467-74. PMID: 20663707
- Childhood ataxia: clinical features, pathogenesis, key unanswered questions, and future directions. | Ashley, CN., et al. 2012. J Child Neurol. 27: 1095-120. PMID: 22859693
- Retinoic acid and histone deacetylases regulate epigenetic changes in embryonic stem cells. | Urvalek, AM. and Gudas, LJ. 2014. J Biol Chem. 289: 19519-30. PMID: 24821725
- Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction. | Mani, SK., et al. 2015. Am J Physiol Heart Circ Physiol. 308: H1391-401. PMID: 25795711
- Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. | Schoepflin, ZR., et al. 2016. J Bone Miner Res. 31: 1287-99. PMID: 26765925
- Histone deacetylase inhibitors containing a benzamide functional group and a pyridyl cap are preferentially effective human immunodeficiency virus-1 latency-reversing agents in primary resting CD4+ T cells. | Kobayashi, Y., et al. 2017. J Gen Virol. 98: 799-809. PMID: 28113052
- A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. | He, X., et al. 2018. Nat Med. 24: 338-351. PMID: 29431744
- Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1. | Pfister, JA., et al. 2019. PLoS One. 14: e0215208. PMID: 30973934
- Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites. | Coetzee, N., et al. 2020. Sci Rep. 10: 2355. PMID: 32047203
- Marek's disease virus US3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis. | Liao, Y., et al. 2021. PLoS Pathog. 17: e1009307. PMID: 33596269
- The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors. | Khateb, A., et al. 2021. Nat Commun. 12: 5397. PMID: 34518534
- High-Throughput Screening for Epigenetic Compounds That Induce Human β-Defensin 1 Synthesis. | Lyu, W., et al. 2023. Antibiotics (Basel). 12: PMID: 36830097
Inhibitor of:
HDAC1, HDAC2, HDAC3, and HDAC8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pimelic Diphenylamide 106, 1 mg | sc-364589 | 1 mg | $41.00 | |||
Pimelic Diphenylamide 106, 5 mg | sc-364589A | 5 mg | $74.00 |