Pim-3 Antibody (4A9): sc-293237
- Pim-3 Antibody (4A9) is a mouse monoclonal IgG2a κ Pim-3 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against a recombinant protein mapping within amino acids 242-326 of Pim-3 of human origin
- recommended for detection of Pim-3 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pim-3 Antibody (4A9). This work is in progress.
Pim-3 Antibody (4A9) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Pim-3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Pim-3 antibody (4A9) is available as a non-conjugated format. Pim-3, a member of the proto-oncogene Pim family, plays a crucial role in various cellular processes, including cell cycle progression and apoptosis regulation. Pim-3 functions as a serine/threonine kinase that shares significant homology with Pim-1, and Pim-3 expression is particularly important in synaptic plasticity in the brain, where Pim-3 may mediate the strengthening of synapses, a process vital for learning and memory. Pim-3 participates in anti-apoptotic signaling pathways in hematopoietic progenitor cells, which is essential for maintaining cell survival and function. Pim-3 shows widespread expression in various tissues but remains notably absent in the colon, thymus, and small intestine, indicating a specific regulatory role in other cell types. Increased levels of Pim kinases, including Pim-3, have been associated with lymphomagenesis, highlighting Pim-3′s significance in cancer biology.
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Pim-3 Antibody (4A9) References:
- Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP. | Konietzko, U., et al. 1999. EMBO J. 18: 3359-69. PMID: 10369676
- Developmental expression of pim kinases suggests functions also outside of the hematopoietic system. | Eichmann, A., et al. 2000. Oncogene. 19: 1215-24. PMID: 10713710
- PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. | Deneen, B., et al. 2003. Mol Cell Biol. 23: 3897-908. PMID: 12748291
- The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. | Yan, B., et al. 2003. J Biol Chem. 278: 45358-67. PMID: 12954615
- Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. | Qian, KC., et al. 2005. J Biol Chem. 280: 6130-7. PMID: 15525646
- Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. | Fujii, C., et al. 2005. Int J Cancer. 114: 209-18. PMID: 15540201
- The serine/threonine kinase Pim-1. | Bachmann, M. and Möröy, T. 2005. Int J Biochem Cell Biol. 37: 726-30. PMID: 15694833
- Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. | Li, YY., et al. 2006. Cancer Res. 66: 6741-7. PMID: 16818649
- KID-1, a protein kinase induced by depolarization in brain. | Feldman, JD., et al. 1998. J Biol Chem. 273: 16535-43. PMID: 9632723
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pim-3 Antibody (4A9) | sc-293237 | 100 µg/ml | $316.00 |