PILR-α Antibody (47-12): sc-100286
- PILR-α Antibody (47-12) is a mouse monoclonal IgG1 κ PILR-α antibody provided at 100 µg/ml
- raised against recombinant PILR-α of human origin
- recommended for detection of PILR-α of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PILR-α Antibody (47-12). This work is in progress.
PILR-α Antibody (47-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects the PILR-alpha protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PILR-alpha antibody (47-12) is available as a non-conjugated format. PILR-α protein, also known as paired immunoglobulin (Ig)-like type 2 receptor α or FDF03, plays a crucial role in the immune system by functioning as an inhibitory receptor that helps regulate immune responses. PILR-α is predominantly expressed in hematopoietic tissues and is found in various immune cells, including macrophages, monocytes, granulocytes, and dendritic cells. PILR-α recognizes sialylated O-glycosylated ligands, such as MIC2, which are important for cell signaling and immune regulation. PILR-α contains an immune receptor tyrosine-based inhibitory motif (ITIM) that facilitates the recruitment of phosphatases, leading to the inhibition of immune activation. PILR-α exists in four isoforms due to alternative splicing, with isoforms 1 and 2 being single-pass type I membrane proteins that localize to the cell membrane, while isoforms 3 and 4 are secreted proteins. This diversity in isoforms allows for a nuanced regulation of immune responses, making PILR-α a critical component in maintaining immune homeostasis.
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PILR-α Antibody (47-12) References:
- PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. | Mousseau, DD., et al. 2000. J Biol Chem. 275: 4467-74. PMID: 10660620
- FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. | Fournier, N., et al. 2000. J Immunol. 165: 1197-209. PMID: 10903717
- Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. | Shiratori, I., et al. 2004. J Exp Med. 199: 525-33. PMID: 14970179
- A gene signature of inhibitory MHC receptors identifies a BDCA3(+) subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro. | Velten, FW., et al. 2004. Eur J Immunol. 34: 2800-11. PMID: 15368296
- Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. | Wilson, MD., et al. 2006. Physiol Genomics. 27: 201-18. PMID: 16926269
- Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRalpha). | Tabata, S., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 44-6. PMID: 18097101
- Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors. | Tabata, S., et al. 2008. J Biol Chem. 283: 8893-901. PMID: 18234675
- PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. | Satoh, T., et al. 2008. Cell. 132: 935-44. PMID: 18358807
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PILR-α Antibody (47-12) | sc-100286 | 100 µg/ml | $339.00 |