Molecular structure of Pilocarpine nitrate salt, CAS Number: 148-72-1
Pilocarpine nitrate salt (CAS 148-72-1)
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Alternate Names:
3-ethyldihydro-4-[(1-methyl-1h-imidazol-5-yl)methyl]-2(3h)-furanon(3s-cis)
Application:
Pilocarpine nitrate salt is a nonselectivce muscarinic acetylcholine receptor agonist
CAS Number:
148-72-1
Purity:
≥98%
Molecular Weight:
271.27
Molecular Formula:
C11H16N2O2•HNO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pilocarpine nitrate salt activates a specific type of receptor called muscarinic acetylcholine receptors, which are found in various tissues including the eye, salivary glands, and smooth muscle. When pilocarpine nitrate salt binds to these receptors, it stimulates the production of second messengers within the cell, leading to a cascade of intracellular events.This activation ultimately results in the contraction of smooth muscle and increased secretion of saliva and tears. In the eye, pilocarpine nitrate salt can constrict the pupil and improve the drainage of aqueous humor.
Pilocarpine nitrate salt (CAS 148-72-1) References
- Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures. | Andrioli, A., et al. 2009. Epilepsia. 50: 832-48. PMID: 19220411
- Albumin microspheres as an ocular delivery system for pilocarpine nitrate. | Rathod, S. and Deshpande, SG. 2008. Indian J Pharm Sci. 70: 193-7. PMID: 20046711
- Design and evaluation of liposomal formulation of pilocarpine nitrate. | Rathod, S. and Deshpande, SG. 2010. Indian J Pharm Sci. 72: 155-60. PMID: 20838517
- A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate. | Li, J., et al. 2013. Int J Pharm. 455: 75-84. PMID: 23916822
- Proteomics reveals potential non-neuronal cholinergic receptor-effectors in endothelial cells. | Zhang, YY., et al. 2014. Acta Pharmacol Sin. 35: 1137-49. PMID: 25088000
- Central muscarinic and LPBN mechanisms on sodium intake. | Anesio, A., et al. 2019. Brain Res Bull. 144: 14-20. PMID: 30391542
- Self-assembled hexagonal liquid crystalline gels as novel ocular formulation with enhanced topical delivery of pilocarpine nitrate. | Wang, X., et al. 2019. Int J Pharm. 562: 31-41. PMID: 30878587
- Neuroinflammatory Response in Chronic Hydrocephalus in Juvenile Rats. | Olopade, FE., et al. 2019. Neuroscience. 419: 14-22. PMID: 31491504
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- Needle-free iontophoresis-driven β-adrenergic sweat rate test. | Reynaerts, A., et al. 2022. J Cyst Fibros. 21: 407-415. PMID: 34489187
- Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus. | Andrioli, A., et al. 2022. Int J Mol Sci. 24: PMID: 36613467
- Separation and analysis of pilocarpine, isopilocarpine, and pilocarpic acid by reverse phase liquid chromatography: collaborative study. | Van Ackeren, JL., et al. 1984. J Assoc Off Anal Chem. 67: 924-6. PMID: 6501156
- Clozapine inhibits limbic system kindling: implications for antipsychotic action. | Graham, SR. and Kokkinidis, L. 1993. Brain Res Bull. 30: 597-605. PMID: 8096163
- Effects of cattle tick (Boophilus microplus) infestation on the bovine immune system. | Inokuma, H., et al. 1993. Vet Parasitol. 47: 107-18. PMID: 8493757
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pilocarpine nitrate salt, 10 g | sc-250722 | 10 g | $281.00 |