Molecular structure of PIK-III, CAS Number: 1383716-40-2
PIK-III (CAS 1383716-40-2)
CAS Number:
1383716-40-2
Molecular Weight:
319.36
Molecular Formula:
C17H17N7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PIK-III (CAS 1383716-40-2) References
- Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. | Dowdle, WE., et al. 2014. Nat Cell Biol. 16: 1069-79. PMID: 25327288
- Ironing out VPS34 inhibition. | Marsh, T. and Debnath, J. 2015. Nat Cell Biol. 17: 1-3. PMID: 25679028
- Inhibition of Human Class I vs Class III Phosphatidylinositol 3'-Kinases. | Hassett, MR., et al. 2017. Biochemistry. 56: 4326-4334. PMID: 28719179
- 2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway. | Guan, H., et al. 2017. Mol Biosyst. 13: 1993-2005. PMID: 28752163
- Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells. | Djehal, A., et al. 2018. Eur J Med Chem. 155: 880-888. PMID: 29960207
- Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. | Baquero, P., et al. 2019. Leukemia. 33: 981-994. PMID: 30185934
- Macrophage-driven nutrient delivery to phagosomal Staphylococcus aureus supports bacterial growth. | Flannagan, RS. and Heinrichs, DE. 2020. EMBO Rep. 21: e50348. PMID: 32452129
- An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells. | Kobylarz, MJ., et al. 2020. PLoS One. 15: e0235551. PMID: 32833964
- MLN4924 inhibits hedgehog signaling pathway and activates autophagy to alleviate mouse laser-induced choroidal neovascularization lesion. | Xie, L., et al. 2020. Biomed Pharmacother. 130: 110654. PMID: 34321162
- Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia. | Bwanika, HC., et al. 2024. Sci Rep. 14: 4000. PMID: 38369625
Inhibitor of:
Atg10, Atg12, Atg2B, Atg9b, BECN1, DRAM2, MAP LC3α, PI 3-kinase C2y, Ribosomal Protein L13A, Syntaxin 17, UBXD1, Vps34, and WDR47.Activator of:
Atg16, IFN-α6, and PI 3-kinase C2α.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIK-III, 5 mg | sc-507530 | 5 mg | $170.00 |