Molecular structure of PIK-93, CAS Number: 593960-11-3
PIK-93 (CAS 593960-11-3)
Application:
PIK-93 is a novel and potent inhibitor
CAS Number:
593960-11-3
Molecular Weight:
389.88
Molecular Formula:
C14H16ClN3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Safety Information
SDS & Certificate of Analysis
PIK-93 is a novel and potent inhibitor of both PI3Kγ and PI4KIIIβ with IC50 of 16 nM and 19 nM, respectively.
PIK-93 (CAS 593960-11-3) References
- A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. | Knight, ZA., et al. 2006. Cell. 125: 733-47. PMID: 16647110
- Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. | Miller, S., et al. 2010. Science. 327: 1638-42. PMID: 20339072
- Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. | Monet, M., et al. 2012. J Biol Chem. 287: 17672-17681. PMID: 22493444
- Phosphatidylinositol 4-kinases: Function, structure, and inhibition. | Boura, E. and Nencka, R. 2015. Exp Cell Res. 337: 136-45. PMID: 26183104
- Activation of the Ca2+-sensing receptors increases currents through inward rectifier K+ channels via activation of phosphatidylinositol 4-kinase. | Liu, CH., et al. 2016. Pflugers Arch. 468: 1931-1943. PMID: 27838849
- Mitigating Motor Neuronal Loss in C. elegans Model of ALS8. | Zhang, W., et al. 2017. Sci Rep. 7: 11582. PMID: 28912432
- Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections. | McPhail, JA. and Burke, JE. 2020. Adv Exp Med Biol. 1274: 203-222. PMID: 32894512
- Small-molecule PIK-93 modulates the tumor microenvironment to improve immune checkpoint blockade response. | Lin, CY., et al. 2023. Sci Adv. 9: eade9944. PMID: 37027467
- Clustering analysis and prognostic model based on PI3K/AKT-related genes in pancreatic cancer. | Deng, X., et al. 2023. Front Oncol. 13: 1112104. PMID: 37124502
- Molecular Expression and Prognostic Implications of Krüppel-Like Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma. | Wan, B., et al. 2024. Crit Rev Eukaryot Gene Expr. 34: 45-59. PMID: 38073441
Inhibitor of:
BRAG2, copine 1, cytohesin-1, DDEF2, EFR3B, FAM62C, Nir2, PI 3-kinase p110 gamma, PI 4-kinase α, PI 4-kinase β, PI 4-kinase II β, PIPK I α, PIPK I γ, PIPK II α, PIPK II β, PIPK II γ, SAC1_Sac1, SMAP1L, and TMEM55A.Activator of:
1100001G20Rik, CHMP7, FBXW2, MTMR2, ORP-11, OS4, OTUD7A, PI 3-kinase C2β, Rab 31, Rab 43, and SPDL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIK-93, 5 mg | sc-364588 | 5 mg | $255.00 |