Molecular structure of PIK-90, CAS Number: 677338-12-4
PIK-90 (CAS 677338-12-4)
Alternate Names:
PI 3-K inhibitor IX
Application:
PIK-90 is a selective inhibitor of PI3K isoforms
CAS Number:
677338-12-4
Purity:
≥99%
Molecular Weight:
351.36
Molecular Formula:
C18H17N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PIK-90 selectively inhibits different subsets of four class I PI3K isoforms (IC50 = 11, 350, 58, and 18 nM for PI3Kα, -β, -δ, and γ, respectively). In addition, PIK-90 completely inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells, resulting in antiproliferative activity in certain glioma cell lines including U87 MG, SF188, SF763, LN229, A1207 and LN-Z30 cells. In chronic lymphocytic leukemia (CLL) cells, PIK-90 inhibits chemotaxis to levels that are 57.8% of controls at 1 μM and 56.8% of controls at 10 μM.
Inhibitor of:
Akt, Enzyme, PI 3-kinase, PI 3-kinase C2γ, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIK-90, 5 mg | sc-364587 | 5 mg | $107.00 | |||
PIK-90, 50 mg | sc-364587A | 50 mg | $566.00 |