Molecular structure of Pifithrin-α, p-nitro, cyclic, CAS Number: 60477-38-5
Pifithrin-α, p-nitro, cyclic (CAS 60477-38-5)
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Alternate Names:
Pifithrin-α, p-nitro, cyclic is also known as p-nitro-Cyclic PFT-α.
Application:
Pifithrin-α, p-nitro, cyclic is A cell-permeable p53 inhibitor that is more potent & has a longer half-life than Pifithrin-α.
CAS Number:
60477-38-5
Purity:
≥95%
Molecular Weight:
299.35
Molecular Formula:
C15H13N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Pifithrin-α, p-Nitro, Cyclic is a cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37° C) than Pifithrin-α. Pifithrin-α, p-nitro, cyclic behaves p53-dependently but does not block p53 phosphorylation on Ser15 in reponse to etoposide treatment. Pifithrin-α, p-nitro, cyclic will block p53 posttranscriptional activity, however. Pifithrin-α, p-nitro, cyclic is more stable than the parent compound. Pifithrin-α, p-nitro, cyclic is not active in vivo.
Pifithrin-α, p-nitro, cyclic (CAS 60477-38-5) References
- A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. | Komarov, PG., et al. 1999. Science. 285: 1733-7. PMID: 10481009
- Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. | Pietrancosta, N., et al. 2006. J Med Chem. 49: 3645-52. PMID: 16759106
- Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling. | Xu, XL., et al. 2009. Cell. 137: 1018-31. PMID: 19524506
- Nongenotoxic apoptosis inducers do not produce misleading positive results in the TK6 cell-based GADD45a-GFP genotoxicity assay. | Topham, CH., et al. 2012. Toxicol Sci. 128: 79-91. PMID: 22491427
- Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudine induces p53 signaling and apoptosis in HTLV-1-infected cells. | Kinpara, S., et al. 2013. Retrovirology. 10: 52. PMID: 23688327
- An Evaluation Of The Ability Of Pifithrin-Α And -Β To Inhibit P53 Function In Two Wild-Type P53 Human Tumor Cell Lines | Mike I. Walton, et al. 2005. Mol Cancer Ther. 4: 1369–1377.
Inhibitor of:
p53, and Transcription Factor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pifithrin-α, p-nitro, cyclic, 5 mg | sc-222177 | 5 mg | $167.00 | |||
Pifithrin-α, p-nitro, cyclic, 10 mg | sc-222177A | 10 mg | $306.00 | |||
Pifithrin-α, p-nitro, cyclic, 25 mg | sc-222177B | 25 mg | $612.00 | |||
Pifithrin-α, p-nitro, cyclic, 50 mg | sc-222177C | 50 mg | $1122.00 |