Pifithrin-α, p-Nitro (CAS 389850-21-9)
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Pifithrin-α, p-Nitro is a small molecule inhibitor. It is known to inhibit the activity of p53, p53 protein plays a role in regulating cell growth and division. Pifithrin-α, p-Nitro interrupts the transcriptional activity of p53 by hindering its ability to bind to DNA, subsequently altering the expression of p53 target genes. This inhibition of p53 function has important implications for studying the molecular mechanisms underlying cell cycle regulation, DNA repair, and apoptosis. Pifithrin-α, p-Nitro is useful for investigating the role of p53 in various cellular processes and in response to different stress stimuli. Its ability to precisely target p53 activity enables it as a key resource for examining the complex signaling networks that underlie cellular stability.
Pifithrin-α, p-Nitro (CAS 389850-21-9) References
- Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. | Pietrancosta, N., et al. 2006. J Med Chem. 49: 3645-52. PMID: 16759106
- Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate. | Shimizu, H., et al. 2010. Am J Physiol Cell Physiol. 299: C1110-7. PMID: 20720180
- NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. | Shimizu, H., et al. 2011. Am J Physiol Cell Physiol. 301: C1201-12. PMID: 21832251
- Indoxyl sulfate induces endothelial cell senescence by increasing reactive oxygen species production and p53 activity. | Adelibieke, Y., et al. 2012. J Ren Nutr. 22: 86-9. PMID: 22200421
- Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress. | Muteliefu, G., et al. 2012. Am J Physiol Cell Physiol. 303: C126-34. PMID: 22555846
- Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells. | Shimizu, H., et al. 2013. Life Sci. 92: 143-8. PMID: 23201429
- Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. | Derdak, Z., et al. 2013. J Hepatol. 58: 785-91. PMID: 23211317
- Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. | Shimizu, H., et al. 2013. Am J Nephrol. 37: 97-103. PMID: 23363842
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pifithrin-α, p-Nitro, 5 mg | sc-222176 | 5 mg | $134.00 |