Pifithrin-alpha, p-Nitro CAS: 389850-21-9
MF: C15H15N3O3S•HBr
MW: 398.27
A cell-permeable p53 inhibitor.

Pifithrin-α, p-Nitro (CAS 389850-21-9)

Pifithrin-α, p-Nitro | CAS 389850-21-9 is rated 4.5 out of 5 by 2.
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Alternate Names: 1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr
Application: Pifithrin-α, p-Nitro is a cell-permeable p53 inhibitor
CAS Number: 389850-21-9
Purity: ≥97%
Molecular Weight: 398.27
Molecular Formula: C15H15N3O3S•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Pifithrin-α, p-Nitro is a cell-permeable p53 inhibitor that serves as the prodrug form of Pifithrin-α, p-Nitro, Cyclic.


References

1. Pietrancosta, Nicolas., et al., 2006. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. Journal of medicinal chem istry. 49(12): 3645-52. PMID: 16759106
2. Shimizu, H. et al. 2013. Am. J. Nephrol. 37(2): 97-103. PMID: 23363842

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), and ethanol (2.5 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1CCC2=C(C1)N(C(=N)S2)CC(=O)C3=CC=C(C=C3)[N+](=O)[O-].Br

Download SDS (MSDS)

Certificate of Analysis

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Pifithrin-alpha, p-Nitro (CAS 389850-21-9)  Product Citations

See how others have used Pifithrin-alpha, p-Nitro (CAS 389850-21-9). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26431790  Yin, R. et al. 2016. Respir Physiol Neurobiol. 220: 81-7.

PMID: # 25064493  Eleftheriadis, T. et al. 2014. International immunology. 26: 673-84.

Citations 1 to 2 of 2 total
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Rated 4 out of 5 by from Good performance I used this product to inhibit p53 in primary keratinocytes and melanocytes. It worked very well!
Date published: 2017-01-02
Rated 5 out of 5 by from Shimizu H; et al Shimizu H; et al. (PubMed ID: 23363842) showed that Pifithrin- , p-Nitros, a known p53 inhibitor, suppressed TGFB1. -SCBT Publication Review
Date published: 2015-04-20
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